Malignant Mesothelioma Clinical Trial
Official title:
Randomized Feasibility Study Of Active Symptom Control With Or Without Chemotherapy In The Treatment Of Patients With Mesothelioma
Verified date | May 2003 |
Source | National Cancer Institute (NCI) |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Federal Government |
Study type | Interventional |
RATIONALE: Palliative therapy may help patients with advanced cancer live more comfortably.
It is not yet known if palliative therapy is more effective with or without chemotherapy in
treating patients who have malignant mesothelioma.
PURPOSE: Randomized phase II trial to compare the effectiveness of palliative therapy with
or without different chemotherapy regimens in treating patients who have malignant
mesothelioma.
Status | Active, not recruiting |
Enrollment | 0 |
Est. completion date | |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | N/A and older |
Eligibility |
DISEASE CHARACTERISTICS: - Immunohistochemically or cytologically confirmed malignant mesothelioma - Epithelial and other histological types - Symptomatic pleural effusion allowed if treated and controlled by drainage, pleurodesis, or pleurectomy - Prior surgical resection allowed if stable or progressive disease by 2 CT scan measurements at least 6 weeks apart PATIENT CHARACTERISTICS: Age: - Not specified Performance status: - WHO 0-2 Life expectancy: - Not specified Hematopoietic: - WBC greater than 3,000/mm3 - Neutrophil count greater than 1,500/mm3 - Platelet count greater than 100,000/mm3 Hepatic: - Not specified Renal: - Not specified Other: - Considered medically fit to receive chemotherapy - No other disease or prior malignancy that would preclude study - No clinical evidence of infection PRIOR CONCURRENT THERAPY: Biologic therapy: - Not specified Chemotherapy: - No prior chemotherapy for mesothelioma Endocrine therapy: - Not specified Radiotherapy: - Not specified Surgery: - See Disease Characteristics |
Allocation: Randomized, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
United Kingdom | Aberdeen Royal Infirmary | Aberdeen | Scotland |
United Kingdom | Dorothy House Foundation | Bradford-Onavon | |
United Kingdom | St. Peters Hospital | Chertsey Surrey | |
United Kingdom | Stobhill General Hospital | Glasgow | Scotland |
United Kingdom | Princess Royal Hospital | Hull | England |
United Kingdom | Leeds Teaching Hospital Trust | Leeds | England |
United Kingdom | Medical Research Council Clinical Trials Unit | London | England |
United Kingdom | Saint Bartholomew's Hospital | London | England |
United Kingdom | Royal Marsden Hospital | Sutton | England |
Lead Sponsor | Collaborator |
---|---|
British Thoracic Society | Medical Research Council |
United Kingdom,
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