Malignant Melanoma Clinical Trial
Official title:
High Intensity Interval Training (HIIT) on Stationary Bike With and Without Compression Stockings for Patients With Cancer-related Lymphedema in the Lower Limbs - a Feasibility Study
The aim of the study is to explore the feasibility and safety of High Intensity Interval
Training on a stationary bike for patients with lymphedema in the lower limbs and the role of
compression garments during exercise.
The design of the study is a cross-over randomized clinical trial. Participants will be
randomized into two groups. Both will perform two separate exercise sessions.Group A will
perform the first exercise with compression garment and the second session without
compression garment, with wash-out period of 1 week between sessions. Group B will perform
the exercise sessions in the opposite order.
Lymphedema is a condition afflicting cancer patients who undergo surgery with removal of
lymph nodes, chemotherapy and radiation. Lymphedema is a consequence of impaired lymphatic
drainage in the interstitium, which causes edema and inflammation in the subcutaneous tissue.
The symptoms are swelling, puffiness, tightness, heaviness and pain in the affected area.
Lymphedema can be reduced by complete decongestive therapy, which consists of skin care,
manual lymphatic drainage, compression bandaging and exercise. At the end of treatment,
patients are provided with custommade compression garments to be worn during daytime in order
to maintain the reduction in the edema.
Lymphedema has a negative impact on activities of daily living and health-related quality of
life. Patients with lymphedema should be encouraged to engage in physical activity despite
their condition in order to prevent relapse of cancer and development of other diseases.
Likewise physical activity helps to maintain a healthy weight, which is important as obesity
has a negative impact on lymphedema. The lymphatic system is also stimulated by physical
activity and exercise and can reduce the symptoms from the lymphedema.
Several studies have been published on the safety and benefits of exercise for women with
breastcancer related lymphedema. However, only a few studies have investigated the
feasibility of exercise to patients with lymphedema in the lower limbs. Also the role of
compression garments during exercise have not been throughly explored.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04229277 -
Fast Track Diagnosis of Skin Cancer by Advanced Imaging
|
N/A | |
| Active, not recruiting |
NCT04074096 -
Binimetinib Encorafenib Pembrolizumab +/- Stereotactic Radiosurgery in BRAFV600 Melanoma With Brain Metastasis
|
Phase 2 | |
| Completed |
NCT02935790 -
Selective HDAC6 Inhibitor ACY-241 in Combination With Ipilimumab and Nivolumab
|
Phase 1 | |
| Recruiting |
NCT05478876 -
Carbon Ion Radiation Therapy in the Treatment of Mucous Melanomas of the Female Lower Genital Tract
|
N/A | |
| Completed |
NCT01211262 -
Study to Assess the Tolerability of a Bispecific Targeted Biologic IMCgp100 in Malignant Melanoma
|
Phase 1 | |
| Recruiting |
NCT03649529 -
Treatment of Malignant Melanoma With GPA-TriMAR-T Cell Therapy
|
Early Phase 1 | |
| Completed |
NCT03278665 -
4SC-202 in Combination With Pembrolizumab in Patients Primary Refractory/Non-responding to Prior Anti-PD-1 Therapy
|
Phase 1/Phase 2 | |
| Completed |
NCT04452214 -
A Study of the Safety and Tolerance of CAN04 and Pembrolizumab in Combination With and Without Carboplatin and Pemetrexed in Subjects With Solid Tumors
|
Phase 1 | |
| Terminated |
NCT02709889 -
Rovalpituzumab Tesirine in Delta-Like Protein 3-Expressing Advanced Solid Tumors
|
Phase 1/Phase 2 | |
| Completed |
NCT01455259 -
Phase I/IIa AdCD40L Immunogene Therapy for Malignant Melanoma and Other Solid Tumors
|
Phase 1/Phase 2 | |
| Completed |
NCT00978913 -
Transfected Dendritic Cell Based Therapy for Patients With Breast Cancer or Malignant Melanoma
|
Phase 1 | |
| Completed |
NCT00232726 -
Clinical Study of Previously Untreated Patients With Malignant Melanoma
|
Phase 2 | |
| Completed |
NCT00336986 -
Efficacy Study of IL-21 to Treat Metastatic Melanoma
|
Phase 2 | |
| Completed |
NCT00350597 -
GM-CSF as Adjuvant Therapy of Melanoma
|
Phase 2 | |
| Completed |
NCT02523313 -
Immunotherapy With Nivolumab or Nivolumab Plus Ipilimumab vs. Double Placebo for Stage IV Melanoma w. NED
|
Phase 2 | |
| Completed |
NCT03545334 -
Lymph Node Identification in Skin Malignancy Using ICG Transcutaneously Study
|
N/A | |
| Completed |
NCT04253574 -
Comparison of PET/CT and Ultrasound in Staging of Malignant Melanoma
|
||
| Completed |
NCT00179608 -
Study of the Combination of Lenalidomide and DTIC (Dacarbazine) in Patients With Metastatic Malignant Melanoma Previously Untreated With Systemic Chemotherapy
|
Phase 1 | |
| Terminated |
NCT00104884 -
FR901228 in Treating Patients With Unresectable Stage III or Stage IV Malignant Melanoma
|
Phase 2 | |
| Recruiting |
NCT04593485 -
Anti-PD-1 Antibody in the Treatment of Patients With Malignant Melanoma of the Female Genital Tract
|
Phase 2 |