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Malignant Esophagus Tumor clinical trials

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NCT ID: NCT04595149 Recruiting - Clinical trials for Neoplasm, Esophageal

Tapestry: Addition of TGF-β and PDL-1 Inhibition to Definitive Chemoradiation in Esophageal Squamous Cell Carcinoma

TAPESTRY
Start date: November 30, 2020
Phase: Phase 2
Study type: Interventional

The outcome of irresectable oesophaguscancer is poor, despite the fact that curative treatment with definitive chemoradiation is possible. The outcome of treatment can possibly be improved by combining chemoradiation with immunotherapy such as bintrafusp alfa, a combined TGF-β and PD-L1 inhibitor. In this study investigators investigate the feasibility of combining bintrafusp alfa with definitive chemoradiation in patients with irresectable squamous cell carcinoma of the esophagus.