Magnetic Resonance (MR) Guided Focused Ultrasound in the Treatment of Brain Tumors — FUS-Tumor  

Malignant Brain Tumors Clinical Trial

Official title: MR-guided Ultrasound-Neurosurgery for the Treatment of Malignant Brain Tumors

Status Completed

Clinical Trial Summary

Focused Ultrasound Focused ultrasound is an attractive method for non-invasive thermal ablation of soft tissue tumors. Treatment begins by acquiring a series of MR images of the target organ. The physician then identifies a target volume in the MR images and delineates the treatment contours on the images. Therapy planning software calculates the parameters required to effectively treat the defined target volume. During the treatment an ultrasound transducer generates and focuses ultrasound energy to a focal point, called a sonication. The sonication raises the tissue temperature within a well-defined region to a degree, which causes thermal coagulation. MR images acquired during sonication provide a quantitative, real-time temperature map of the target area to confirm the location of the sonication and the size of the coagulated region. The sonication process is repeated at multiple adjacent points to cover the entire prescribed treatment volume.

Clinical Trial Description

n/a

Study Design

Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Brain Neoplasms
• Malignant Brain Tumors

• NCT number: NCT01698437
• Study type: Interventional
• Source: University Children's Hospital, Zurich
• Status: Completed
• Phase: Phase 1
• Start date: February 2011
• Completion date: May 2016