Malaria Clinical Trial
— MMSOfficial title:
Infections in Migrants in Sweden - the Importance of Malaria and Other Parasitic Infections
NCT number | NCT05086887 |
Other study ID # | MMS2019 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | April 15, 2019 |
Est. completion date | June 30, 2023 |
Malaria is a parasitic disease causing substantial morbidity and mortality globally. Malaria is a potentially severe and fatal disease in non-immune individuals. In areas of intense transmission infections individuals acquired immunity that protect against clinical disease. Nonetheless, immunity is not regarding sterilizing and repeated infections often result in an asymptomatic carriage of malaria parasites. These chronic apparently asymptomatic infections have been associated with anemia, cognitive dysfunction and adverse events during pregnancy. Global migration has increased over the last decade and has resulted in an increasing number of migrants from malaria endemic regions arriving in non-endemic countries. Migrants from malaria endemic countries may carry asymptomatic infections with malaria parasites, as well as other parasitic infections such as strongyloides and schistosomiasis, with a possible negative impact on health in this group. The prevalence of asymptomatic malaria and other parasites is not fully elucidated in migrants from different regions. Moreover, the longevity of asymptomatic carriage of malaria parasites in absence of re-exposure is not known. The aim of this study is to assess the prevalence of malaria parasites and other parasitic infections in migrants in Sweden, both newly arrived and migrants with longer residency, and intend to evaluate the need for screening for various parasitic infections in migrants arriving in Sweden. Moreover, this study will also assess antibody responses to malaria and other parasitic diseases.
Status | Recruiting |
Enrollment | 715 |
Est. completion date | June 30, 2023 |
Est. primary completion date | January 1, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | N/A and older |
Eligibility | Inclusion Criteria: - Born in a malaria endemic country (a country with reported indigenous spread of malaria according to World Malaria Report 2019) Exclusion Criteria: - Inability to understand study information or sign informed consent, except for children where legal guardian is asked for consent. |
Country | Name | City | State |
---|---|---|---|
Sweden | Asylum Health Care Facilities in SLSO and Karolinska University Hospital | Stockholm |
Lead Sponsor | Collaborator |
---|---|
Region Stockholm |
Sweden,
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* Note: There are 23 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Parasite prevalence | Number of participants with ongoing malaria infection | Measured at one occasion within 10 years from arrival in Sweden | |
Primary | Prevalence of other parasites focusing on strongyloides and schistosomiasis | Number of participants showing serological response to strongyloides and schistosomiasis | Measured at one occasion within 10 years from arrival in Sweden | |
Secondary | Immune responses to malaria and other parasites | Levels and breadth of P. falciparum specific antibody and memory B cell responses. | A blood specimen will be collected from participants upon inclusion, and a subset of volunteers will be asked to contribute with a second blood sample after 6-12 months |
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