Malaria Clinical Trial
Official title:
Safety and Protective Efficacy of BCG Vaccination Against Controlled Human Malaria Infection
The Bacillus Calmette-Guérin (BCG) vaccine, a live attenuated Mycobacterium bovis vaccine,
has been used to prevent tuberculosis for almost a century, and it is still the most used
vaccine in the world. There is also circumstantial and indirect evidence that BCG
vaccination can protect against malaria. Investigators hypothesize that BCG vaccination can
offer protection against malaria in the Controlled Human Malaria Infection (CHMI) model.
A total of 20 healthy male and female volunteers will participate in this randomized,
single-blind clinical trial. Volunteers will be randomized to receive either BCG vaccination
(BCG vaccine SSI) (group 1, n=10) or no treatment (group 2, n=10). Five weeks after
vaccination of group 1 volunteers, all volunteers will undergo a CHMI administered by the
bites of five P. falciparum infected Anopheles mosquitoes.
n/a
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