Malaria Clinical Trial
A longitudinal study on immune responses in relation to protection against clinical malaria
episodes will be conducted in Apac District, Uganda. Three cohorts will be recruited:
children 1 to 5 years of age (n=250), children 6 to 10 years of age (n=125) and adults 25
and above (n=125). After finger prick sampling (~300µL) and examination at enrolment,
participants will be followed up for one year. Follow-up will include fortnightly active
case detection and three-monthly cross-sectional surveys. Clinical malaria attacks and the
associated clinical and parasitological parameters will be related to immunological profiles
determined utilizing a protein microarray as a capture substratum to profile the humoral
immune response against a vast number of parasite antigens.
For individuals who experience a clinical malaria attack or who are diagnosed with high
density parasitaemia (≥15,000 parasites/µL) during cross-sectional surveys, a 5mL blood
sample is obtained to determine the diversity of parasite antigens in the population in
relation to antigen recognition in the cohort.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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|---|---|---|---|
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