Effect of a Combined Use of Mosquito Repellent and Insecticide Treated Net on Malaria in Ethiopia

Malaria Clinical Trial

Official title:

Effect of a Combined Use of Mosquito Repellent and Insecticide Treated Net on Malaria in Southern Ethiopia: a Cluster-randomized Controlled Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01160809
• Other study ID #: 0001
• Status: Completed
• Phase: Phase 4
• First received: July 8, 2010
• Last updated: July 9, 2010
• Start date: September 2008
• Est. completion date: January 2009

Study information

• Verified date: July 2010
• Source: Malaria Consortium, Ethiopia
• Contact: n/a
• Is FDA regulated: No
• Health authority: Ethiopia: Ministry of Ethiopian Science and Technology
• Study type: Interventional

Clinical Trial Summary

The combined use of a mosquito repellent and long lasting insecticidal nets (LLINs) by household members would result in a 40% reduction in malaria prevalence compared with households that only use LLINs.

Description:

It has been recognized that the use of malaria preventive measures in combination with LLINs could improve the effectiveness of nets in preventing the disease. This study examined the effect of a combined use of mosquito repellent (i.e., Buzz Off) and LLINs on malaria prevalence in an area of unstable and seasonal malaria transmission.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 6082
• Est. completion date: January 2009
• Est. primary completion date: December 2008
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• All volunteer household members

Exclusion Criteria:

• Infants less than two months

• Not in the study area

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Related Conditions & MeSH terms

• Long Lasting Insecticidal Nets
• Malaria
• Mosquito Repellent

Intervention

Other:
• Mosquito repellent
Mosquito repellent (Buzz Off jelly) every evening applied to face, neck, hands and legs

Locations

Country	Name	City	State
Ethiopia	SNNPR, Ethiopia	Awassa	Snnpr

Sponsors (4)

Lead Sponsor	Collaborator
Malaria Consortium, Ethiopia	Addis Ababa University, Coalition Against Malaria in Ethiopia, Columbia University

Country where clinical trial is conducted

Ethiopia, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Malaria parasite (P. falciparum and/or P. vivax)through microscopic detection	The objective of the study is to investigate the impact of a combined use of mosquito repellent and LLINs in reducing malaria. The primary outcome of the study is detection of malaria parasites (P. falciparum and/or P. vivax) through examination of microscopic blood slides collected from finger-pricks.		No
Secondary	Household ownership and utilization of LLINs	Owneship and utilization of LLINs by household members during the night before the baseline survey		No