Malaria Clinical Trial
Official title:
Role and Effectiveness of Rapid Diagnostic Tests in Home-based Management of Malaria: Comparative Trials in Two Areas of High and Low Transmission in Uganda
Most malaria deaths occur within 48 hours of onset of symptoms, and in rural areas with poor
access to health facilities, home management of malaria (HMM) can improve the timeliness of
treatment and reduce malaria mortality by up to 50%. In order to maximize both coverage and
impact, ACTs should be deployed in HMM programmes, as well as in formal health facilities.
Up to 80% of malaria cases are treated outside the formal health sector and shops are
frequently visited as the first (and in some cases only) source of treatment. Strategies to
deploy ACTs in Africa thus also need to examine the role of shops in home management and to
ensure that drugs sold are appropriate. The current practice of presumptive treatment of any
febrile illness as malaria (both at health facilities and in the context of HMM) based
solely on clinical symptoms without routine laboratory confirmation, results in significant
over-use of antimalarial drugs. With ACT being a more costly regimen, it is important to be
more restrictive in its administration and rapid diagnostic tests (RDTs) provide a simple
means of confirming malaria diagnosis in remote locations lacking electricity and qualified
health staff.
This study therefore proposes to evaluate the feasibility, acceptability, and
cost-effectiveness of using RDTs to improve malaria diagnosis and treatment by
community-based drug distributors.The accuracy of RDTs, and the acceptability of this
approach, will be evaluated in both low and high transmission areas.
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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