Malaria Clinical Trial
Official title:
Age of Exposure and Immunity to Malaria in Infants
The overall objective is to evaluate the effect of exposure to Plasmodium (P.) falciparum
erythrocytic stage antigens during different periods of infancy on the development of
naturally acquired immunity (NAI).
Hypothesis: Exposure to P. falciparum prior to 5 months of age does not result in the
development of NAI, while exposure to P. falciparum after 5 months of age leads to the
development of NAI. The risks of clinical malaria and anaemia during the second year of life
will be compared between cohorts, as well as their correlations with the type and quality of
immune responses (antibodies to several P. falciparum antigens, cytokines), oxidative stress
markers and host genetic factors. These results should shed light on the determinants of the
development of anti-P. falciparum responses early in life and the potential constraints to
early life immunisation.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
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