VAC071: A Study to Assess Efficacy of the ChAd63/MVA PvDBP Vaccines

Status Completed

Clinical Trial Summary

This is an open label, Phase IIa, controlled human malaria infection (CHMI) study aimed to assess whether the new vivax malaria vaccines ChAd63 PvDBP and MVA PvDBP can protect against malaria infection. The participants will receive one or two doses of ChAd63 PvDBP followed by one dose of MVA PvDBP 8 weeks later. Approximately 4 weeks after the second vacccination, the volunteers will be challenged (deliberately infected) with malaria by intravenous injection blood-stage

Clinical Trial Description

Volunteers will be recruited and vaccinated at the CCVTM, Oxford. There will be two groups vaccinated in the trial, with an optional third group included if fewer than 6 volunteers complete group 2. Up to 19 volunteers will be included in total. These will be compared to a matched number of infectivity controls, receiving no vaccination, who will be recruited as part of a separate study (VAC069 - NCT03797989). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04009096
Study type	Interventional
Source	University of Oxford
Contact
Status	Completed
Phase	Phase 2
Start date	July 18, 2019
Completion date	July 7, 2022

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