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Study of Fibrinogen Metabolism During Severe Trauma and Burns

Burn Injury Clinical Trial

Official title:
Alteration in Fibrinogen Metabolism in Patients With Severe Burns and Traumatic Injuries

Clinical Trial Summary

To study the fibrinogen metabolic changes in relation to coagulation disorder in patients with severe burns and trauma injuries. As a result of the burn or trauma injury breakdown of fibrinogen is accelerated.

Clinical Trial Description

In this protocol, we will investigate fibrinogen metabolism in burn and trauma patients, using an 8h infusion of stable isotopes labeled amino acids (1-13C-phenylalanine, 2H5-phenylalanine, and 2H3-ketoisocaporate). The increase of the labeled amino acids incorporating into fibrinogen during the infusion and the decay of labeled fibrinogen after stopping the isotopes infusion (as measured by GC-MS) will be used to calculate fibrinogen synthesis and degradation. Stable isotopes are non-radioactive. ;

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00588796
Study type Observational
Source United States Army Institute of Surgical Research
Contact
Status Completed
Phase N/A
Start date February 2005
Completion date January 2014
View Details
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