Major Depression Clinical Trial
Official title:
The Effect of Transcranial Direct Current Stimulation (tDCS) on Cognitive Control and Emotion Regulation in Depressed Patients
Deficient cognitive control (CC) and the use of dysfunctional emotion regulation strategies (ERS) are both central characteristics of major depression. Both are associated with reduced activity of the dorsolateral prefrontal cortex (dlPFC). Transcranial direct current stimulation (tDCS) is a safe, simple and effective non-invasive method to modulate the cortical excitability. The goal of this randomized, sham-controlled, double blind clinical trial is to examine the effect of transcranial direct current stimulation (tDCS) on the CC and ERS in depressed patients compared to healthy subjects. Overall, the study will include 44 participants (22 depressed Patients and 22 healthy subjects). Each participant will complete a CC task while receiving sham tDCS in one session and anodal tDCS in the other session (counterbalanced). Afterwards the ERS 'rumination' will be measured during a resting phase by means of a questionnaire and psychophysiological measures (heart rate variability). The investigators hypothesize (a) an amelioration of CC by anodal tDCS and (b) a reduced use of the dysfunctional emotion regulation strategy 'rumination' after anodal tDCS. Overall this experiment will provide new and reliable data for the development of new treatment methods.
1. Working hypothesis: anodal transcranial direct current stimulation (tDCS) of the
dorsolateral prefrontal cortex (dlPFC) can enhance healthy and impaired cognitive
control (CC) and reduce the use of dysfunctional emotion regulation strategies.
2. Previous work of the investigators: The investigators previous work has provided
decisive evidence for polarity-specific activity-dependent effects of tDCS to the left
dlPFC on cognitive planning and control of emotional information processing in healthy
subjects and patients with MD. Particularly, reduced prefrontal brain activity during a
working memory task in patients with MD was found by using near infrared spectroscopy
(NIRS). In addition, the investigators demonstrated that a single session, anodal,
activity enhancing tDCS to the left dlPFC ameliorates deficient CC in patients with
depression, whereas cathodal, activity reducing tDCS, induces a depression-like
negativity bias in healthy subjects. Furthermore, the investigators showed that during
anodal tDCS of the left dlPFC healthy subjects showed (a) better performance in a CC
task (b) no increase in angry mood after the task compared to a control group and (c)
that elevated angry mood was associated to a worse performance in the CC task.
3. Aims and workplan: to investigate the effects of anodal tDCS of the left dLPFC in
healthy and depressed subjects the investigators will conduct a double-blind,
randomized, sham-controlled, cross-over design. In two sessions each participant (22
depressed and 22 healthy subjects, N= 44) will complete a CC task while receiving
anodal tDCS (1 mA) to the left dlPFC in one session and sham tDCS in the other session
(counterbalanced). Afterwards the ERS 'rumination' will be measured during a resting
phase by means of a questionnaire and psychophysiological measures.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03062150 -
Mineralocorticoid Receptor, NMDA Receptor and Cognitive Function in Depression
|
N/A | |
| Completed |
NCT04352101 -
Bupropion Versus Escitalopram on Reward Circuitry and Motivational Deficits
|
Phase 4 | |
| Completed |
NCT02855918 -
Blood Biomarkers in Suicidal Behaviour
|
N/A | |
| Recruiting |
NCT02213016 -
Effectiveness of Repetitive Transcranial Magnetic Stimulation in Depressed Patients
|
Phase 4 | |
| Completed |
NCT01683539 -
Understanding How Cognitive Remediation Works
|
N/A | |
| Completed |
NCT01636791 -
CBT Versus a Return to Work Intervention for Patients With Common Mental Illness in Primary Care
|
Phase 3 | |
| Recruiting |
NCT02237937 -
Optimizing Antidepressant Treatment by Genotype-dependent Adjustment of Medication According to the ABCB1 Gene
|
Phase 4 | |
| Completed |
NCT01201148 -
Open Pilot Trial of TES for Depression
|
Phase 2 | |
| Completed |
NCT00953108 -
Quetiapine Prolong, Escitalopram and Hypothalamic-pituitary-adrenocortical (HPA) Axis Activity in Depressed Patients
|
Phase 3 | |
| Terminated |
NCT01244711 -
Open-Label Pilot Study to Examine the Value of Substituting Quetiapine for Benzodiazepines
|
Phase 4 | |
| Terminated |
NCT00695552 -
The Effect of Exercise on Depressive Symptoms in Unmedicated Patients
|
N/A | |
| Completed |
NCT00711737 -
Study of the Changes in Metabolic Parameters in Patients Treated With Escitalopram for Six Months
|
N/A | |
| Completed |
NCT00806143 -
Bilateral Versus Monolateral Repetitive Transcranial Stimulation in Depression
|
Phase 4 | |
| Completed |
NCT00482482 -
Yoga in Unipolar and Bipolar Disorders
|
N/A | |
| Completed |
NCT00532480 -
Study of Brain Response to Emotional Pictures Using a fMRI While on Duloxetine
|
Phase 4 | |
| Completed |
NCT00466323 -
The Effectiveness of FMPO in Improving the Quality of Care for Persons With Severe Mental Illness.
|
N/A | |
| Completed |
NCT00616759 -
The Effect on Cognition of Terminating ECT Induced Seizures With Propofol
|
N/A | |
| Recruiting |
NCT00209807 -
Effect of Escitalopram vs. Reboxetine on Gastro-intestinal Sensitivity of Patients With Major Depressive Disorder
|
Phase 4 | |
| Completed |
NCT00167310 -
Decreasing Risk of Coronary Artery Disease in Schizophrenia by Omega-3 Fatty Acid Supplementation
|
Phase 2 | |
| Completed |
NCT00149110 -
Chronos: the Use of Chronobiological Treatment in Depression
|
N/A |