Major Depression Clinical Trial
Official title:
Optimizing Antidepressant Treatment by Genotype-dependent Adjustment of Medication According to the ABCB1 Gene
The study evaluates the ABCB1-genotype dependent efficacy of a quick dose-escalation
strategy within 28 days of treatment with approved antidepressants that are known substrates
of the P-glycoprotein, an efflux pump of the blood-brain barrier expressed by the ABCB1
gene.
Moreover, the study evaluates ABCB1-genotype dependent side-effects of approved
antidepressants that are known substrates of the P-glycoprotein, an efflux pump of the
blood-brain barrier expressed by the ABCB1 gene.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Investigator, Outcomes Assessor)
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