Major Depression Clinical Trial
Official title:
The Effects of Sevoflurane or Ketamine on QTc Interval During Electroconvulsive Therapy
Verified date | June 2013 |
Source | Inonu University |
Contact | n/a |
Is FDA regulated | No |
Health authority | Turkey: Ethics Committee |
Study type | Interventional |
The aim of this study was to evaluate the effect of sevoflurane or ketamine on the QTc and Tp-e interval during in patients with major depression.
Status | Completed |
Enrollment | 24 |
Est. completion date | May 2013 |
Est. primary completion date | April 2013 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 60 Years |
Eligibility |
Inclusion Criteria: - Unpremedicated - American Society of Anesthesiologists (ASA) I-II the patients - Major depressions patients scheduled for ECT sessions Exclusion Criteria: - pregnant - with permanent pacemakers, - diabetes mellitus, - atrial fibrillation, - electrolyte imbalance, - patients taking antiarrhythmics and ß-blockers. |
Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Turkey | Turgut Ozal Medical Center | Malatya |
Lead Sponsor | Collaborator |
---|---|
Inonu University |
Turkey,
Erdil F, Demirbilek S, Begec Z, Ozturk E, Ersoy MO. Effects of propofol or etomidate on QT interval during electroconvulsive therapy. J ECT. 2009 Sep;25(3):174-7. doi: 10.1097/YCT.0b013e3181903fa5. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Evaluation Of QT interval | ECG were recorded before anesthetic induction (T1), after anesthetic induction (T2) and at 0, 1, 3, 10 min after the seizure ended (T3, T4, T5 and T6, respectively)during ECT anesthesia with sevoflurane and ketamine.The QT interval was measured by one author, who was unaware of group allocation. | 10 minutes | Yes |
Secondary | Evaluation of Tp-e interval | ECG were recorded before anesthetic induction (T1), after anesthetic induction (T2) and at 0, 1, 3, 10 min after the seizure ended (T3, T4, T5 and T6, respectively)during ECT anesthesia with sevoflurane and ketamine.The Tp-e interval was measured by one author, who was unaware of group allocation. | 10 minutes | Yes |
Secondary | Seizure durations | The duration of the EEG seizure was recorded from the EEG trace, and the peak heart rate (HR) during the convulsion was recorded from the ECG. | 120 seconds | Yes |
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