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NCT04993196 Clinical Trial

Quantitative T1rho Magnetic Resonance Imaging in Healthy Subjects

Magnetic Resonance Imaging Clinical Trial

Official title:
Quantitative T1rho Magnetic Resonance Imaging in Healthy Subjects

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT04993196
Other study ID # TSo
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date August 1, 2021
Est. completion date June 1, 2025

Study information
Verified date February 2023
Source Chinese University of Hong Kong
Contact Tiffany So
Phone +85235051035
Email tiffanyso@cuhk.edu.hk
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

T1rho imaging is a new MRI technique that has strong potential in neuroimaging. This technique does not require exogenous contrast agents and has high spatial resolution. In this study we aim to characterise the normal appearance of T1rho in the brain parenchyma in healthy participants. T1rho values will be measured in normal brain structures.

Recruitment information / eligibility
Status Recruiting
Enrollment 30
Est. completion date June 1, 2025
Est. primary completion date May 31, 2025
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Male and female volunteers greater than or equal to 18 years of age Exclusion Criteria: - Subjects with a contraindication to magnetic resonance imaging such as the presence of metallic implants, claustrophobia and pregnancy. - Subjects with previous severe allergic or anaphylactoid reaction to a gadolinium contrast agent, or contraindication to contrast gadolinium administration, such severe renal disease or acutely deteriorating renal function, who would be at risk of nephrogenic systemic fibrosis - Subjects who are unable to tolerate the scan without moving the head as a result of symptoms such as tremor, spasticity, involuntary movements and spasms, cognitive impairment, coughing, and shortness of breath.

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• T1rho imaging
Magnetic Resonance Imaging using T1rho

Locations
Country Name City State
Hong Kong CUHK Hong Kong

Sponsors (1)
Lead Sponsor Collaborator
Chinese University of Hong Kong

Country where clinical trial is conducted

Hong Kong, 

Outcome
Type Measure Description Time frame Safety issue
Primary T1rho value in normal grey and white matter in healthy volunteers T1rho value (measured on T1rho weighted MRI) in normal grey and white matter in healthy volunteers Up to 2 months
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