Magnetic Resonance Imaging Clinical Trial
Official title:
The Evaluation of D-glucose Weighted Chemical Exchange Saturation Transfer (gluceoCEST)-Based Dynamic Glucose Enhanced(DGE) Magnetic Resonance Imaging(MRI) in Brain Tumor
Verified date | July 2021 |
Source | Zhujiang Hospital |
Contact | Zhibo Wen, PhD |
Phone | 020-643461 |
zhibowen[@]163.com | |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Recently, natural D-glucose was suggested as a potential biodegradable contrast agent. The feasibility of using D-glucose for dynamic perfusion imaging was explored to detect malignant brain tumors based on blood brain barrier breakdown. Our study try to evaluate the feasibility of dynamic glucose enhanced(DGE) magnetic resonance imaging(MRI)in brain tumor, which based on D-glucose weighted chemical exchange saturation transfer (gluceoCEST).
Status | Recruiting |
Enrollment | 100 |
Est. completion date | June 30, 2023 |
Est. primary completion date | June 30, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 75 Years |
Eligibility | Inclusion Criteria: - Patient must have a brain mass consistent with a primary brain tumor or metastatic brain tumor - able to give consent and willingness to participate in this study. Exclusion Criteria: - presence of any ferromagnetic implant (cardiac pacemakers, aneurysm clip, etc.) - pregnancy - claustrophobia or anxiety disorder - history of vertigo - persons with diabetes mellitus (self-report or HbA1C >= 6.5%) - Sickle cell disease - persons taking prescription medicine for hypertension - blood iron deficiency (Hb concentration < 11 g/dL or Hct < 32%) - If volunteering for MRI: history of kidney disease and/or eGFR < 60. - Middle-ear disorder - double vision - Seizure disorder - Multiple myeloma - Solid organ transplant - History of severe hepatic disease/liver transplant/pending liver transplant |
Country | Name | City | State |
---|---|---|---|
China | Zhujiang Hospital of Southern Medical University | Guangzhou | Guangdong |
Lead Sponsor | Collaborator |
---|---|
Zhujiang Hospital |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | CEST value of tumor lesion including tumor core/ necrosis/ cysis/ edema | the CEST value of tumor core and necrosis might higher than white matter | 1 week |
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