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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT04448613
Other study ID # 2020-A00502-37
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date June 17, 2020
Est. completion date June 2024

Study information

Verified date July 2023
Source Fondation Ophtalmologique Adolphe de Rothschild
Contact amé YAVCHITZ
Phone 0148036431
Email ayavchitz@for.paris
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The presence of optic disc swelling at the fundus is a non-specific clinical sign that can occur in many ophthalmologic, neuro-ophthalmologic or encephalic pathologies. The diagnostic range is vast, including inflammatory pathologies of the optic nerve, infiltrative or compressive orbital pathologies, idiopathic or secondary intracranial hypertensions, not to mention the pseudo optic disc swelling found in drüsens. MRI is increasingly being used as a first-line examination to obtain an etiologic diagnosis in a patient with optic disc swelling. It allows a rapid diagnosis to be made in cases of inflammatory pathology or compressive or infiltrative pathology. It can provide very suggestive elements in the case of intracranial hypertension. It appears to be potentially useful in diagnosing ischemic optic neuropathy or in directing towards an etiological diagnosis of Giant Cell Arteritis. The development of new high-resolution MRI sequences has made it possible to obtain extremely fine resolutions of a few hundred microns in the plane. Apart from a few clinical cases and small series, there is no precise evaluation of the interest of these new sequences in the positive and etiological diagnosis of ophthalmological, neuro-ophthalmological and encephalic pathologies responsible for the presence of optic disc swelling. The objective of our study is therefore to evaluate the diagnostic contribution and the gain in diagnostic confidence provided by these new sequences in the context of pathologies manifesting as optic disc swelling.


Recruitment information / eligibility

Status Recruiting
Enrollment 250
Est. completion date June 2024
Est. primary completion date June 2024
Accepts healthy volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Patient over 18 years old - presenting a papillary edema detected clinically at the back of the eye - Express consent to participate in the study - Affiliate or beneficiary of a Social Security scheme Exclusion Criteria: - MRI contraindication (electrical device, metallic foreign body, claustrophobia) - Patient benefiting from a legal protection measure - Pregnant or breastfeeding woman

Study Design


Related Conditions & MeSH terms


Intervention

Other:
MRI
Patients with optic disc swelling diagnosed by a fundus and included in the study will have a brain MRI and visual pathways lasting 30 minutes. Two additional 10-minute sequences will be added to the standard protocol.

Locations

Country Name City State
France Fondation Ophtalmologique Adolphe de Rothschild (FOR) Paris

Sponsors (1)

Lead Sponsor Collaborator
Fondation Ophtalmologique Adolphe de Rothschild

Country where clinical trial is conducted

France, 

Outcome

Type Measure Description Time frame Safety issue
Primary FLAIR hypersignal size: larger diameters and area larger diameters and area of FLAIR hypersignal baseline
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