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Response Prediction for Anti-angiogenic Treatment in Recurrent Glioblastoma

Magnetic Resonance Imaging Clinical Trial

Official title:
Prospective Observational Study of Imaging-based Response Prediction for Anti-angiogenic Treatment in Recurrent Glioblastomas

Clinical Trial Summary

This study aims to evaluate whether pre-treatment MRI can be used to predict treatment response for anti-angiogenic treatment in glioblastomas.

Clinical Trial Description

Although overall the effects on prolonging survival in bevacizumab-treated patients is modest at best, it is still unclear whether there is not a more substantial positive effect in a subset of patients, potentially identifiable by imaging markers. Allowing for prediction of good or bad responder from anti-angiogenic therapy prior to treatment completion is important to select patients most likely to benefit from anti-angiogenic treatment. This is a prospective observational study and no active comparator will be used. Study participants include adult patients with recurrent glioblastoma. We hypothesized that quantifying changes in multi-modal advanced MR imaging techniques would allow early treatment response and long-term prediction in glioblastomas. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04143425
Study type Observational
Source Asan Medical Center
Contact
Status Completed
Phase
Start date February 6, 2020
Completion date November 1, 2022
View Details
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