Magnetic Resonance Imaging Clinical Trial
Official title:
Effects of Nonsteroidal Anti-inflammatory Drug (NSAID) on Inflammatory Lesion of Axial Spondyloarthritis Results From MRI Finding
Verified date | June 2018 |
Source | Armed Forces Capital Hospital, Republic of Korea |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Axial Spondyloarthritis (SpA) is a kind of inflammatory arthritis which includes ankylosing
spondylitis. Common symptoms of axial SpA are inflammatory back pain, morning stiffness,
peripheral arthritis, enthesitis. Controlling aforementioned symptoms are one of the goal in
treatment, and another goal is preventing bony ankylosis of axial skeleton such as spine.
Ankylosis can limit range of motion and lower the quality of life.
Non-steroidal antiinflammatory drug (NSAID) and Tumor necrosis factor (TNF)-a inhibitor are
the current treatment options for axial SpA. These medications can improve pain and stiffness
of axial SpA patients, however preventing bony ankylosis is not proven. Current study showed
attenuating inflammation at early stage could prevent further bony destruction and ankylosis
in axial SpA. Present study is designed to discover the therapeutic effect of NSAID whether
NSAID could recover the early inflammatory bony change (bone marrow edema at MRI) and prevent
further bony change.
Status | Completed |
Enrollment | 12 |
Est. completion date | June 5, 2018 |
Est. primary completion date | June 5, 2018 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 30 Years |
Eligibility |
Inclusion Criteria: 1. 2009 Assessment of SpondyloArthritis international Society (ASAS) classification criteria for axial spondyloarthritis 2. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) > 4 3. definite bone marrow edema on Sacroiliac joint MRI Exclusion Criteria: 1. Patients who have underling cancer / infectious disease / kidney disease / liver disease / cardiovascular or cerebrovascular disease 2. Patients who is using TNF-a inhibitor 3. Patients with side effects of NSAID 4. Patients with history of peptic ulcer 5. Patients who can't keep NSAID treatment |
Country | Name | City | State |
---|---|---|---|
Korea, Republic of | Armed Forces Capital Hospital | Seongnam-si |
Lead Sponsor | Collaborator |
---|---|
Armed Forces Capital Hospital, Republic of Korea |
Korea, Republic of,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Spondyloarthritis Research Consortium of Canada (SPARCC) MRI score of sacroiliac joint | Change from baseline SPARCC MRI score of sacroiliac joint at 6 weeks and 12 weeks | Baseline, 6 weeks after, 12 weeks after |
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