Muscle Cramp Clinical Trial
Official title:
Prevention of Leg Cramps Using Compression Stockings or Magnesium Supplements in the Age Group of 50 to 84: a Study Protocol for a Randomised Controlled Trial
Leg cramps are painful sensations of tightening in the muscles of the legs, that are often associated with secondary insomnia. They are common especially at an older age. There is no evidence that any method of prevention of nocturnal leg cramps would be both safe and effective. There are no previous trials concerning cramp prevention by using compression stockings. The objective of this study is to assess in a prospective randomised controlled trial whether leg cramps can be prevented by daily use of knee-length compression stockings or magnesium supplements.
Leg cramps are painful sensations of tightening in the muscles of the legs that commonly appear during the night and are often associated with secondary insomnia. They are common especially in older age. There is no evidence that any method of prevention of nocturnal leg cramps is both safe and effective. There are no previous trials concerning cramp prevention by using compression stockings. The objective of this study is to assess in a prospective randomised controlled trial whether leg cramps can be prevented by the daily use of knee-length compression stockings or magnesium supplements. Methods The study will be set in Finland, and 50-84-year-old volunteers will be recruited through Google Ads, the Finnish Health Library and Finnish primary health care centres. The participants must have a minimum of two episodes of leg cramps per week for the past four weeks to be included in the study. The participants (n = 225) will be allocated to three equal groups: the compression stocking arm, the magnesium supplement arm and the placebo arm. The participants will go through four weeks of follow-up without intervention, and then another four weeks of follow-up with the assigned intervention. The material for the study will be collected through electronic questionnaires. Discussion This protocol describes a study that compares compression stockings, magnesium supplements and placebo for the prevention of leg cramps. The results of this study can significantly improve knowledge on the methods of preventing leg cramps. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04998305 -
TJ-68 Clinical Trial in Patients With Amyotrophic Lateral Sclerosis (ALS) and Muscle Cramps
|
Phase 1/Phase 2 | |
| Completed |
NCT03176966 -
Ropinirole for the Treatment of Muscle Cramps in Patients With Cirrhosis
|
Phase 4 | |
| Completed |
NCT04575090 -
7 Tesla MRI Study in Patients With Statin Related Muscle Complaints
|
N/A | |
| Completed |
NCT01271660 -
A Study Evaluating the Efficacy and Safety of Pregabalin Against Frequent Muscle Cramp in Patients With Liver Cirrhosis
|
Phase 3 | |
| Terminated |
NCT00516516 -
Oral Carnitine for Cramps in Pregnancy
|
N/A | |
| Completed |
NCT04650295 -
Non-Pharmaceutical Intervention for Cirrhotic Cramps Reduction: The NICCles Trial
|
N/A | |
| Recruiting |
NCT03660969 -
Reliability of Cardiac Troponins for the Diagnosis of Myocardial Infarction in the Presence of Skeletal Muscle Disease
|
||
| Completed |
NCT03802565 -
Tolperisone in Acute Muscle Spasm of the Back
|
Phase 2 | |
| Completed |
NCT04901832 -
Intradialytic Stretching Exercises on Prevention and Reduction of Leg Muscle Cramps
|
N/A | |
| Completed |
NCT05457322 -
The RELAX Trial: Nonpharmaceutical Intervention for Nocturnal Muscle Cramps
|
N/A | |
| Terminated |
NCT04507373 -
7T Magnetic Resonance Spectroscopy and Skeletal Muscle Biopsy Findings in Statin Associated Adverse Muscle Events
|
Phase 4 | |
| Completed |
NCT00963638 -
Beneficial Effects of Magnesium Supplementation On Idiopathic Muscle Cramps
|
N/A | |
| Completed |
NCT05724485 -
Effect of Branched-chain Amino Acids (BCAA) to Muscle Cramps in Patients With Cirrhosis
|
Phase 4 |