Macular Degeneration Clinical Trial
Official title:
VEGF Gene Polymorphism and Response to Intravitreal Anti-VEGF Agents in Neovascular Age-related Macular Degeneration
| NCT number | NCT01655589 |
| Other study ID # | IV-01 |
| Secondary ID | |
| Status | Recruiting |
| Phase | N/A |
| First received | July 31, 2012 |
| Last updated | July 31, 2012 |
| Start date | January 2008 |
| Verified date | July 2012 |
| Source | Institute of Vision, Brasil |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | Brazil: National Committee of Ethics in Research |
| Study type | Observational |
The main purpose of this study is to investigate the association between VEGF gene polymorphism and the response to intravitreal drugs in neovascular age-related macular degeneration. This is a retrospective review of patients treated between 2008 and 2012 at the Institute of Vision, in Belo Horizonte, Brazil.
| Status | Recruiting |
| Enrollment | 74 |
| Est. completion date | |
| Est. primary completion date | |
| Accepts healthy volunteers | No |
| Gender | Both |
| Age group | 50 Years and older |
| Eligibility |
Inclusion Criteria: - Diagnosis of neovascular age-related macular degeneration - Visual acuity better than 20/400 - Loading dose with three intravitreal injections of anti-VEGF agents, administred one per month over three months - Follow-up period of at least six months Exclusion Criteria: - Choroidal neovascularization secondary to any other cause than age-related macular degeneration - Eyes with polypoidal choroidal vasculopathy - Eyes previously submitted to posterior vitrectomy - Other diseases that could affect visual acuity |
Observational Model: Case-Only, Time Perspective: Retrospective
| Country | Name | City | State |
|---|---|---|---|
| Brazil | Institute of Vision | Belo Horizonte | MG |
| Lead Sponsor | Collaborator |
|---|---|
| Institute of Vision, Brasil |
Brazil,
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