Macular Degeneration Clinical Trial
Official title:
Intravitreal Bevacizumab Combined With Intravitreal Triamcinolone Acetonide Injection Versus Intravitreal Bevacizumab for Age Related Macular Degeneration
Exudative age related macular degeneration (ARMD) is most common cause of blindness in old
population. It is clear that no single therapy addresses the multifactorial pathogenesis of
the disease. Recently, studies of intravitreal anti-VEGF therapies such as pegaptanib and
bevacizumab have shown the beneficial effect in visual acuity in the treatment of
neovascular ARMD. However, the problem with these intravitreal injections is that therapy
must be frequently administered for a prolonged but unknown period of time to maintain the
benefit. Prolonged, frequent injections may be associated with additional safety risk,lack
of convenience and high treatment cost.
Intravitreal steroid injection with anti-inflammatory properties limits any further VEGF
upregulation initiated by the inflammation which has been known as one of the pathogenesis
and causes of recurrence after the treatment of the neovascular ARMD.
The researchers hypothesize that the combined treatment of intravitreal bevacizumab and
triamcinolone acetonide may decrease the recurrence rate after the treatment and obviate the
frequent intravitreal injections in the treatment of neovascular ARMD.
In this study, the researchers will compare the recurrence rate of combined treatment of
intravitreal bevacizumab and triamcinolone acetonide versus intravitreal bevacizumab alone
in the treatment of neovascular ARMD.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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