Macular Degeneration Clinical Trial
Official title:
An Open-label, Phase I, Single Administration, Dose- Escalation Study of AdGVPEDF.11D in Neovascular Age-related Macular Degeneration (AMD)
The primary purpose of this study is to assess the safety of AdGVPEDF.11D when given to
patients with "wet" age-related macular degeneration (AMD). AdGVPEDF.11D is a replication
deficient (E1, E3 and E4 deleted) adenovirus vector containing the gene for the PEDF
(pigment epithelium-derived factor) protein. PEDF is a protein that naturally exists in the
human eye, but whose levels are altered in diseases characterized by ocular
neovascularization like AMD. The PEDF protein is known to have anti-angiogenic effects or,
in other words, it has the ability to inhibit growth of new blood vessels.
AdGVPEDF.11D will be delivered once via intravitreal injection into one eye. The injected
eye will be the eye with the worst visual acuity.
n/a
Endpoint Classification: Safety Study, Masking: Open Label, Primary Purpose: Treatment
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