Methadone, Morphine, or Oxycodone in Treating Pain in Patients With Cancer

Status Terminated

Clinical Trial Summary

RATIONALE: Methadone, morphine, or oxycodone may help relieve pain caused by cancer. It is not yet known whether methadone is more effective than morphine or oxycodone in treating pain in patients with cancer.

PURPOSE: This randomized clinical trial is studying methadone to see how well it works compared with morphine or oxycodone in treating pain in patients with cancer.

Clinical Trial Description

OBJECTIVES:

Primary

- To compare the effectiveness of an opioid rotation to oral methadone versus an opioid rotation to another long-acting strong opioid (sustained-release morphine or oxycodone) in controlling pain (i.e., analgesia) in patients with cancer.

Secondary

- To compare the tolerability of an opioid rotation to oral methadone versus an opioid rotation to another long-acting strong opioid (sustained-release morphine or oxycodone).

- To identify a subset of patients most likely to benefit from an opioid rotation to oral methadone, in terms of significant improvement in pain control or opioid tolerability.

OUTLINE: This is a multicenter study. Patients are stratified according to their baseline opioid (morphine vs oxycodone). Patients are randomized to 1 of 2 treatment arms.

- Arm I: Patients are switched from their current opioid medication (oxycodone or morphine) to methadone. Patients receive oral methadone 2-3 times daily for 4 weeks.

- Arm II: Patients currently receiving oxycodone are switched to sustained-release (SR) morphine. Patients currently receiving morphine are switched to SR oxycodone. Patients receive either oral SR morphine or oxycodone 2-3 times daily for 4 weeks.

Patients are assessed for pain control and complete a symptom questionnaire on days 1, 8, 15, 22, and 28. ;

Study Design

Related Conditions & MeSH terms

Brain and Central Nervous System Tumors
Central Nervous System Neoplasms
Chronic Myeloproliferative Disorders
Disease
Leukemia
Lymphoma
Lymphoproliferative Disorder
Lymphoproliferative Disorders
Multiple Myeloma
Multiple Myeloma and Plasma Cell Neoplasm
Myelodysplastic Syndromes
Myelodysplastic-Myeloproliferative Diseases
Myelodysplastic/Myeloproliferative Neoplasms
Myeloproliferative Disorders
Neoplasms
Neoplasms, Plasma Cell
Nervous System Neoplasms
Pain
Precancerous Condition
Precancerous Conditions
Preleukemia
Syndrome
Unspecified Adult Solid Tumor, Protocol Specific

Clinical Trial Details

NCT number	NCT00726830
Study type	Interventional
Source	M.D. Anderson Cancer Center
Contact
Status	Terminated
Phase	N/A
Start date	March 2009
Completion date	October 2010

View Details

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