Elastography and Treatment of Lymphoma

Lymphoma Clinical Trial

Official title:

The Role of Sonoelastography in Evaluation of Therapeutic Response in Patients With Lymphoma.

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05967975
• Other study ID #: Elastography and lymphoma
• Status: Not yet recruiting
• Start date: August 2023
• Est. completion date: December 2025

Study information

• Verified date: July 2023
• Source: Assiut University
• Contact: Kero Refaat, Resident
• Phone: +2 01110134427
• Email: kerolsrefaat13[@]gmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

To determine accuracy of elastography in assessment of superficial lymph nodes response to treatment in cases of lymphoma.

Description:

Lymphomas are a heterogeneous group of malignancies that arise from the clonal proliferation of lymphocytes. It represents approximately 5% of malignancies. Overall survival is estimated to be 72%. (1)

Lymphomas are broadly classified into Hodgkin lymphoma (HL) (10%) and Non-Hodgkin lymphoma (NHL) (90%).

HL is further classified into classical and non-classical types and NHL into B-cell, T-cell and natural killer (NK) cell types. Diagnosis of lymphoma is confirmed by histopathology (FNAC, True-cut or excisional biopsy).(2) The standard treatment of lymphoma is chemotherapy and radiotherapy.

The modalities used for staging and follow up of lymphoma are:

• Computed Tomography (CT) chest, abdomen and pelvis.

• Positron Emission Tomography (PET/CT).

• Whole body Magnetic Resonance Imaging (MRI).(3)

Sonoelastography is a new technique that depends on the elastic properties of soft tissues, with the idea of malignant lesions being stiffer than benign or normal tissue. It may have a dependable role in evaluation of therapeutic response in patients with lymphoma and can be used for follow up, the same way it has been used in different parts of the body, such as the breast, and thyroid. To the best of our knowledge, there are few studies concerning the role of elastography in the field of lymphoma disease.(4)

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 44
• Est. completion date: December 2025
• Est. primary completion date: November 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• patients who are histopathologically proven as lymphoma, not receive treatment and have superficial lymphadenopathy.

Exclusion Criteria:

• 1-Lymphoma without superficial lymph nodes. 2-patients under treatment.

Related Conditions & MeSH terms

• Elastography
• Lymphoma

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	To determine accuracy of elastography in assessment of superficial lymph nodes response to treatment in cases of lymphoma.	Sonoelastography is a new technique that depends on the elastic properties of soft tissues, with the idea of malignant lesions being stiffer than benign or normal tissue. It may have a dependable role in evaluation of therapeutic response in patients with lymphoma and can be used for follow up, the same way it has been used in different parts of the body, such as the breast, and thyroid. To the best of our knowledge, there are few studies concerning the role of elastography in the field of lymphoma disease.	Average three years