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NCT05095155 Clinical Trial

Study of the Prognostic Role of Gene Polymorphism in the Development of B-cell Leukemias and Lymphomas in Children of Kazakh Nationality

Lymphoma Clinical Trial

Official title:
Preventive and Personalized Medicine (2021-2023)

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05095155
Other study ID # 1190
Secondary ID
Status Completed
Phase
First received
Last updated
Start date April 1, 2022
Est. completion date January 20, 2023

Study information
Verified date March 2023
Source Asfendiyarov Kazakh National Medical University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

To search for a genetic marker of B-cell leukemias and lymphomas in children of Kazakh nationality, a single nucleotide polymorphism (SNP) analysis of DNA obtained from the peripheral blood of patients with B-cell leukemias and lymphomas in children of Kazakh nationality and normal control will be performed.

Recruitment information / eligibility
Status Completed
Enrollment 400
Est. completion date January 20, 2023
Est. primary completion date January 20, 2023
Accepts healthy volunteers
Gender All
Age group 0 Years to 18 Years
Eligibility Inclusion Criteria: - ethnicity - Kazakhs in at least three generations - active disease or a history of B-line ALL or B-NHL, established on the basis of morphological, cytochemical, immunophenotypic or immunohistochemical research methods with confirmation of the fact of the disease in medical documentation - Signed voluntary informed consent of the legal representative to participate in the project Exclusion Criteria: - Children suffering from other types of malignant neoplasms - Children with B-linear leukemia and lymphomas with concomitant specified genetic and chromosomal diseases - Children of non-Kazakh nationality - Absence of signed informed consent or informed refusal of the legal representative to participate in the study before starting therapy

Study Design

Related Conditions & MeSH terms

Intervention

Genetic:
• SNP analysis of the DNA
SNP analysis of the DNA obtained from peripheral blood sample

Locations
Country Name City State
Kazakhstan Scientific Center of Pediatrics and Pediatric Surgery Almaty

Sponsors (1)
Lead Sponsor Collaborator
Asfendiyarov Kazakh National Medical University

Country where clinical trial is conducted

Kazakhstan, 

Outcome
Type Measure Description Time frame Safety issue
Primary Associated with B-cell lymphoma and B-cell acute lymphoblastic leukemia Genotype frequency of SNP in the study genes of participants and control participants. 1 year
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