Polymorphisms at Distinct Genetic Loci Affect Response to Anti-CD20 Monoclonal Antibody Therapies

Lymphoma Clinical Trial

Official title: Polymorphisms at Distinct Genetic Loci Affect Response to Anti-CD20 Monoclonal Antibody Therapies

Status Completed

Clinical Trial Summary

This is a non-interventional, R01-funded pilot study that will identify serum and cellular markers in patients' blood samples that can be used as short-term biomarkers of rituximab response. We hypothesize that serum complement levels, activation of natural killer cells, and clearance of peripheral B-cells will be accurate biomarkers of rituximab response, and may be correlated with long-term outcomes.

Clinical Trial Description

This study does not involve the administration of study drug. This study will only require additional blood draws to identify how patients respond to rituximab and other anti-CD20 antibody therapy. It is expected that blood draws will occur on the same day in which an IV is placed to dose you with the anti-CD20 antibody or for other bloodwork being performed in order to avoid extra sticks.

If you take part in this study, you will have additional blood drawn at the following time-points surround anti-CD20 antibody therapy:

Pre Dose, Cycle 1

• Two 7.5 ml tubes (two teaspoons) of blood will be taken along with your other pre-chemotherapy bloodwork Post Dose, Cycle 1

• Two 5 ml tubes (three teaspoons) of blood will be taken Pre Dose, Cycle 2

• Two 5 ml tubes (two teaspoons) of blood will be taken Post Dose, Cycle 2

• Two 5 ml tubes (two teaspoons) of blood will be taken Pre Dose, Cycle 6

• Two 10 ml tubes (four teaspoons) of blood will be taken Post Dose, Cycle 6

• Two 10 ml tubes (four teaspoons) of blood will be taken

Note: Two tubes will be taken at each draw. If no blood was drawn in the prior 8 weeks, 10 ml of blood will be taken per tube. For the first 4 draws (at cycle 1 and cycle 2, pre- and post-), the amount of blood being taken is to ensure that the patient does not have more than 50 ml of blood taken within an 8 week period. ;

Related Conditions & MeSH terms

• Lymphoma

• NCT number: NCT02694913
• Study type: Observational
• Source: Weill Medical College of Cornell University
• Status: Completed
• Start date: November 2015
• Completion date: February 7, 2019