Lymphoma Clinical Trial
Official title:
Pilot Study of Brentuximab Vedotin in CD30 Positive EBV Positive Diffuse Large B-Cell Lymphomas of the Elderly
The main purpose of this study is to test if brentuximab vedotin has an effect on cancer in patients with a certain type of large B-Cell Lymphoma. The side effects (unwanted effects) of SGN-35 in patients with this certain type of large B-Cell Lymphoma will also be studied. It is not known if brentuximab vedotin is better or worse than other treatment that might be given.
Brentuximab vedotin is a type of drug called an antibody drug conjugate (ADC). ADCs usually
have 2 parts; a part that targets cancer cells (the antibody) and a cell killing part (the
chemotherapy). Antibodies are proteins that are part of the immune system. They can stick to
and attack specific targets on cells. The antibody part of brentuximab vedotin sticks to a
target called CD30. CD30 is an important molecule on some cancer cells (including
non-Hodgkin lymphoma) and some normal cells of the immune system. The cell killing part of
brentuximab vedotin is a chemotherapy called monomethyl auristatin E (MMAE). After the
brentuximab vedotin attaches to the CD30 part of the cell, the MMAE enters the cell and
kills it.
More than 350 people with cancer have already been given brentuximab vedotin in research
studies. These research studies were done to test the safety of different doses of
brentuximab vedotin and to find out if brentuximab vedotin is active against cancer.
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Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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