Lymphoma Clinical Trial
Official title:
Signaling in Tumorigenesis and Immunity
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory
may help doctors identify and learn more about biomarkers related to cancer. It may also
help doctors find better ways to treat cancer.
PURPOSE: This research trial studies gene expression in samples from patients with T-cell
acute lymphoblastic leukemia.
OBJECTIVES:
- To test whether the tumor suppressor candidate gene PDLIM2 is downregulated in human
cancers such as T-cell acute lymphoblastic leukemia (T-ALL) and to use the human
T-lymphotropic virus 1 (HTLV-1)-mediated in vitro transformation of human T cells as
control.
OUTLINE: Previously collected cancer and control tissues are analyzed for the expression
patterns of PDLIM2 and other control genes. Human T-cells isolated from human blood are also
co-cultured with HTLV-1-transformed T-cell lines.
;
Observational Model: Case-Only, Time Perspective: Retrospective
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