Lymphoma Clinical Trial
Official title:
Investigation to Evaluate the Levels of Human Germinal-center-Associated Lymphoma (HGAL) Protein in Pediatric Hodgkin Lymphoma and Correlate With Early Response
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help
doctors identify and learn more about changes that occur in DNA and identify biomarkers
related to cancer. It may also help doctors predict how patients will respond to treatment.
PURPOSE: This research trial is studying protein biomarker levels in tissue samples from
young patients with low-risk Hodgkin lymphoma.
OBJECTIVES:
- To investigate the variability of expression of human geminal-center-associated
lymphoma (HGAL) protein in pediatric low-risk Hodgkin lymphoma.
- To assess the variability of HGAL staining between risk groups by comparing samples
from subjects enrolled in the low-risk study AHOD0431 with subject samples enrolled in
AHOD0031 for intermediate-risk classical Hodgkin Lymphoma (cHL).
- To assess the variability of HGAL staining by evaluating a tissue array created from
subjects with intermediate-risk cHL.
- To correlate rapid or slow early-response in the intermediate-risk group with HGAL
protein expression.
OUTLINE: Paraffin-embedded tissue samples and tissue microarrays are analyzed for protein
expression by IHC.
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Observational Model: Case Control, Time Perspective: Prospective
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