Lymphoma Clinical Trial
Official title:
Dapsone Induced Methemoglobinemia Study (DIMS)
RATIONALE: Gathering information about patients with childhood hematologic cancer or
aplastic anemia treated with dapsone may help doctors learn more about risk factors for
developing methemoglobinemia.
PURPOSE: This phase I trial is studying methemoglobinemia in patients with childhood
hematologic cancer or aplastic anemia treated with dapsone.
OBJECTIVES:
Primary
- Determine host-related risk factors for developing symptomatic methemoglobinemia in
patients with pediatric hematologic malignancies or aplastic anemia who received
dapsone prophylaxis for pneumocystis carinii.
- Determine whether a deficiency in cytochrome b5 reductase is a risk factor for
symptomatic methemoglobinemia in a subset of these patients.
Secondary
- Collect a genomic DNA specimen from a subset of patients for whom enzyme testing is
being conducted to store for future analyses of variations in the genes responsible for
cytochrome b5 reductase.
OUTLINE: Patients' medical records are reviewed for possible risk factors (e.g., age, sex,
and body mass index) for developing symptomatic methemoglobinemia.
A subset of patients undergo blood sample collection for analysis of cytochrome b5 reductase
levels. DNA samples are also collected from these patients for future genetic polymorphism
studies.
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N/A
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