Lymphoma Clinical Trial
Official title:
Using the Transcriptome for Early Detection of Graft Versus Host Disease in Allogeneic Bone Marrow Transplantation
RATIONALE: Studying samples of blood in the laboratory from patients who have undergone a
donor bone marrow transplant may help doctors learn more about changes that occur in DNA and
identify biomarkers related to graft-versus-host disease. It may also help doctors predict
how patients will respond to a donor bone marrow transplant.
PURPOSE: This laboratory study is looking at early detection of graft-versus-host disease in
patients undergoing a donor bone marrow transplant.
OBJECTIVES:
Primary
- Identify detectable changes in the transcriptomic or proteomic expression prior to
clinical manifestations of graft-versus-host disease (GVHD) in blood samples from
at-risk patients who have undergone allogeneic bone marrow transplantation.
Secondary
- Characterize changes in the transcriptome or proteome expression pattern which are
predictive of clinically significant GVHD in these patients.
- Develop reliable tests which enable early intervention for these patients.
OUTLINE: Blood samples are collected prior to and just after typical onset of clinical
graft-vs-host disease (GVHD) on days 1, 7-10, 20-23, 30-33, and 60 after allogeneic bone
marrow transplantation. RNA is quantified and assessed by microarray analysis to identify
changes to transcriptome or proteome expression and markers predictive of the onset of
clinical GVHD. Samples are also stored for future analysis.
;
Observational Model: Cohort, Time Perspective: Prospective
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