Lymphoma Clinical Trial
Official title:
Pilot Study of RCVELP as First Line Therapy for Follicular Lymphoma (FL) and Marginal Zone Lymphoma (MZL)
RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer growth in different
ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and
help kill them or carry cancer-killing substances to them. Drugs used in chemotherapy, such
as cyclophosphamide and prednisone, work in different ways to stop the growth of cancer
cells, either by killing the cells or by stopping them from dividing. Bortezomib may stop the
growth of cancer cells by blocking some of the enzymes needed for cell growth and by blocking
blood flow to the tumor. Giving rituximab together with cyclophosphamide, bortezomib, and
prednisone may kill more cancer cells.
PURPOSE: This clinical trial is studying how well giving rituximab together with
cyclophosphamide, bortezomib, and prednisone works as first-line therapy in treating patients
with stage III or stage IV follicular lymphoma or marginal zone lymphoma.
OUTLINE:
- Induction therapy: Patients receive rituximab IV and cyclophosphamide IV over 30 minutes
on day 1, bortezomib IV on days 1 and 8, and oral prednisone once daily on days 1-5.
Treatment repeats every 21 days for up to 8 courses in the absence of disease
progression or unacceptable toxicity. Patients then proceed to maintenance therapy.
- Maintenance therapy: Patients receive rituximab IV on days 1, 8, 15, and 22. Treatment
repeats every 6 months for up to 4 courses in the absence of disease progression or
unacceptable toxicity.
After completion of study therapy, patients are followed every 4 months for 1 year, every 6
months for 2 years, and then annually thereafter.
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