Lymphoma Clinical Trial
Official title:
Safety Study to Determine the Maximum Tolerated Dose, Pharmacokinetics and Pharmacodynamics of Oral MP470, a Multi-Targeted Tyrosine Kinase Inhibitor, in Patients With Solid Malignancies
RATIONALE: MP470 may stop the growth of cancer cells by blocking some of the enzymes needed
for cell growth.
PURPOSE: This clinical trial is studying the side effects and best dose of MP470 in treating
patients with unresectable or metastatic refractory solid tumor, Hodgkin's lymphoma, or
non-Hodgkin's lymphoma.
OBJECTIVES:
Primary
- Estimate the maximum tolerated dose (MTD) and define the safety profile of
multitargeted receptor tyrosine kinase inhibitor MP470 in humans.
Secondary
- Estimate the therapeutic response rate for patients receiving MP470.
- Define the human pharmacokinetic (PK) and pharmacodynamic (PD) profiles of MP470
capsules
- Evaluate PK-PD relationships.
OUTLINE: This is a multicenter study.
Patients receive oral multitargeted receptor tyrosine kinase inhibitor MP470 until the
maximum tolerated dose is determined.
Pharmacokinetic and pharmacodynamic analyses are carried out to determine changes in
phosphorylation of extracellular signal-regulated kinase (ERK), Rad51 expression, number of
circulating tumor cells (CTCs), and tumor glucose metabolism measured by
2-[18F]fluoro-2-deoxyglucose positron emission tomography (FDG-PET).
;
Primary Purpose: Treatment
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