Lymphoma Clinical Trial
Official title:
Multicenter Randomized Phase II Study of Methotrexate (MTX) and Temozolomide Versus MTX, Procarbazine, Vincristine and Cytarabine for Primary CNS Lymphoma (PCNSL) in the Elderly
The purpose of this study is to evaluate two types of chemotherapy for primary central
nervous system lymphoma in the elderly (age older than 60) :
- Methotrexate, procarbazine, vincristine and cytarabine
- Methotrexate and temozolomide
The aim of the study is to evaluate efficacy and toxicity associated with both protocols in
this population, without radiotherapy.
Patients will be randomized to receive one of the two regimens in one of the participating
centers. Neuropsychological evaluation will be performed in all patients. Patients will be
followed with serial MRIs.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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