Lymphoma Clinical Trial
Official title:
Phase II Trial of Dolastin 10 in Indolent Lymphoma and Chronic Lymphocytic Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing
so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of dolastatin 10 in treating patients
with indolent lymphoma, Waldenstrom's macroglobulinemia, or chronic lymphocytic leukemia.
OBJECTIVES:
- Estimate the efficacy of dolastatin 10 in patients with indolent lymphoma,
Waldenstrom's macroglobulinemia, or chronic lymphocytic leukemia.
- Evaluate the qualitative and quantitative toxicities of dolastatin 10 in this patient
population.
- Investigate the mechanism of action of dolastatin 10 in regards to apoptosis and
effects of microtubules.
OUTLINE: This is an open-label, multicenter study. Patients are stratified by disease
(chronic lymphocytic leukemia vs indolent lymphoma vs Waldenstrom's macroglobulinemia).
All patients receive dolastatin 10 IV bolus every 3 weeks. Patients continue treatment until
disease progression, unacceptable toxicity, or patient's withdrawal from the study.
PROJECTED ACCRUAL: A maximum of 74 patients will be accrued for this study over 15 months.
;
Masking: Open Label, Primary Purpose: Treatment
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