Lymphoma Clinical Trial
Official title:
Phase II Study of Rituximab (Rituxan, Mabthera) in Waldenstrom's Macroglobulinemia
RATIONALE: Monoclonal antibodies can locate tumor cells and either kill them or deliver
tumor-killing substances to them without harming normal cells.
PURPOSE: Phase II trial to study the effectiveness of rituximab in treating patients who have
Waldenstrom's macroglobulinemia.
OBJECTIVES: I. Determine the objective response, time to treatment failure, and toxicity in
patients with Waldenstrom's macroglobulinemia treated with rituximab. II. Correlate
expression and changes in expression of CD20 on patient plasma cells and B-cells with
clinical responses.
OUTLINE: This is a multicenter study. Patients receive rituximab IV weekly for 4 weeks.
Treatment may be repeated 2 months later in patients with stable disease, partial response,
or complete response. Patients are followed every 6 months for 2 years.
PROJECTED ACCRUAL: A total of 12-25 patients will be accrued for this study.
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