Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer or Nonmalignant Hematologic Disease

Lymphoma Clinical Trial

Official title:

A Multicenter Study of Unrelated Umbilical Cord Blood as an Alternate Source of Stem Cells for Transplantation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00003913
• Other study ID #: 1330.00
• Secondary ID: FHCRC-1330.00UMN
• Status: Completed
• Phase: Phase 2
• First received: November 1, 1999
• Last updated: March 31, 2010
• Start date: December 1998
• Est. completion date: August 2005

Study information

• Verified date: March 2010
• Source: Fred Hutchinson Cancer Research Center
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal GovernmentUnited States: Food and Drug AdministrationUnited States: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Umbilical cord blood transplantation may be able to replace immune cells that were destroyed by the chemotherapy or radiation therapy that was used to kill cancer cells.

PURPOSE: Phase II trial to study the effectiveness of umbilical cord blood transplantation plus combination chemotherapy in treating patients who have hematologic cancer or nonmalignant hematologic disease.

Description:

OBJECTIVES:

• Determine the efficacy of umbilical cord blood transplantation, as measured by durable neutrophil engraftment, in patients with malignant or nonmalignant hematological disease.

• Determine the disease-free survival and long-term survival in patients treated with this regimen.

• Determine the incidence of neutrophil engraftment, primary and secondary graft failure, platelet engraftment, and RBC engraftment in patients treated with this regimen.

• Determine the incidence and severity of acute and chronic graft-versus-host disease, complications (infection, veno-occlusive disease, interstitial pneumonitis), relapse, other malignancies, lymphoproliferative disorders, and posttransplantation myelodysplasia in patients treated with this regimen.

• Determine the immune reconstitution in patients treated with this regimen.

OUTLINE: This is a multicenter study. Patients are stratified according to disease group (malignant vs nonmalignant). Patients with malignant disease are further stratified according to quality of HLA match (1 or 2/6 vs 3/6 vs 4/6 vs 5/6 or 6/6), cell dose, and age.

Patients are assigned to one of three conditioning regimens, depending on disease.

• Group A (malignant disease ): Patients undergo total body irradiation (TBI) once on day -8 and twice daily on days -7 to -4. Male patients with acute lymphocytic leukemia (ALL) undergo radiotherapy boost to testes. Patients receive cyclophosphamide (CTX) IV on days -3 and -2 and methylprednisolone (MePRDL) IV and anti-thymocyte globulin (ATG) IV on days -3 to -1.

• Group B (inborn errors of metabolism/storage disease): Patients receive oral busulfan (BU) every 6 hours on days -6 and -5, CTX IV on days -4 and -3, and MePRDL IV and ATG IV every 12 hours on days -2 and -1.

• Group C (other nonmalignant diseases): Patients receive oral BU every 6 hours on days -9 to -6, CTX IV on days -5 to -2, and MePRDL IV and ATG IV on days -3 to -1.

Patients in all groups receive cord blood IV over a maximum of 30 minutes on day 0. Patients also receive MePRDL IV with the first half of the infusion administered immediately before the cord blood infusion and filgrastim (G-CSF) IV beginning 4 hours after transplantation and continuing until blood counts recover.

Patients are followed at 30, 60, and 90 days; at 6 months; and then annually thereafter.

PROJECTED ACCRUAL: Approximately 390 patients will be accrued for this study within 5 years.

Other known NCT identifiers

• NCT00053755

Recruitment information / eligibility

• Status: Completed
• Enrollment: 390
• Est. completion date: August 2005
• Est. primary completion date: August 2005
• Accepts healthy volunteers: No
• Gender: Both
• Age group: N/A to 18 Years

Eligibility

DISEASE CHARACTERISTICS:

• One of the following diagnoses:

• Acute myeloid leukemia (AML), with or without myelodysplastic syndromes

• Not in first complete remission (CR)* with translocations t(8;21) and inv (16) unless failure of first-line induction therapy

• Not in first CR* with translocations t(15;17) abnormality unless:

• Failure of first-line induction therapy OR

• Molecular evidence of persistent disease

• Not in first CR with Down syndrome

• Patients with third or greater medullary relapse or refractory disease (other than primary induction failures) receive busulfan/melphalan conditioning regimen NOTE: * CR defined by no greater than 5% blasts in marrow

• Acute lymphocytic leukemia (ALL)

• Not in first CR OR

• High-risk ALL in first CR, with high risk defined as one of the following:

• Hypoploidy (no greater than 44 chromosomes)

• Pseudodiploidy with translocations or molecular evidence of t(9;22), 11q23, or t(8;14) (except B-cell ALL) with or without MLL gene arrangement

• Elevated WBC at presentation

• Age 6-12 months: greater than 100,000/mm^3

• Age 10-17 years: greater than 200,000/mm^3

• Age 18: greater than 20,000/mm^3

• Failed to achieve CR after 4 weeks of induction therapy

• Patients with B-ALL must not be in first CR, must meet at least one of the high-risk criteria specified above, or must not meet any of the following criteria:

• Translocation t(8;14)

• Blasts have surface immunoglobulins

• CD10 positive

• Patients with third or greater medullary relapse or refractory disease (other than primary induction failures) receive busulfan/melphalan conditioning regimen

• Chronic myelogenous leukemia, meeting criteria for 1 of the following:

• Accelerated phase

• Chronic phase if 1 year from diagnosis without a matched unrelated bone marrow donor AND unresponsive to or unable to tolerate interferon

• Blast crisis, defined as greater than 30% promyelocytes plus blasts in bone marrow

• Patients receive busulfan/melphalan conditioning regimen

• Acute undifferentiated leukemia (AUL), infant leukemia, or biphenotypic leukemia

• Patients with third or greater medullary relapse or refractory disease (other than primary induction failures) receive busulfan/melphalan conditioning regimen

• Juvenile myelomonocytic leukemia meeting the following criteria:

• No Philadelphia chromosome

• Bone marrow blasts less than 30%

• Peripheral blood monocytes greater than 1,000/mm^3

• At least 2 of the following:

• Peripheral blood spontaneous growth and/or sargramostim (GM-CSF) hypersensitivity

• Increased hemoglobin F for age

• Clonal abnormalities (e.g., monosomy 7 or RAS mutations)

• Peripheral blood with myeloid precursors

• WBC greater than 10,000/mm^3

• Myelodysplastic syndromes defined by the following:

• Refractory anemia (RA)

• RA with ringed sideroblasts

• RA with excess blasts (RAEB)

• RAEB in transformation

• Chronic myelomonocytic leukemia

• Paroxysmal nocturnal hemoglobinuria

• Hodgkin's lymphoma or non-Hodgkin's lymphoma beyond first CR or primary induction failures AND chemosensitive (greater than 50% reduction in tumor mass size)

• Inborn error of metabolism including, but not limited to, Hurler's syndrome, adrenoleukodystrophy (ALD), Maroteaux-Lamy syndrome, globoid cell leukodystrophy, metachromatic leukodystrophy, fucosidosis, or mannosidosis

• For ALD patients over age 5, IQ must be at least 80

• For all other patients over age 5, IQ must be at least 70

• For all patients age 5 and under, developmental quotient or clinical neurodevelopmental examination should demonstrate potential for stabilization at a level of functioning where continuous life support (e.g., mechanical ventilation) would not be predicted to be required in the year after transplantation

• Combined immune deficiencies including, but not limited to:

• Severe combined immunodeficiency (SCID) requiring cytoreduction

• Wiskott-Aldrich syndrome

• Leukocyte adhesion defect

• Chediak-Higashi disease

• X-linked lymphoproliferative disease

• Adenosine deaminase deficiency

• Purine nucleoside phosphorylase deficiency

• X-linked SCID

• Common variable immune deficiency

• Nezelof's syndrome

• Cartilage hair hypoplasia

• No dyskeratosis congenita

• No ALL, AML, AUL, or biphenotypic leukemia in third or higher medullary relapse or refractory disease other than primary induction failure

• No primary myelofibrosis or myelofibrosis grade 3 or worse

• No active CNS leukemia involvement (CSF with WBC greater than 5/mm^3 and malignant cells on cytospin)

• No consenting 5/6 or 6/6 HLA-matched related donor available

• 3-6/6 HLA-matched unrelated umbilical cord blood donor available

PATIENT CHARACTERISTICS:

Age:

• See Disease Characteristics

• 18 and under

Performance status:

• Karnofsky 70-100%, if age 16 to 18

• Lansky 50-100%, if under age 16

Life expectancy:

• Not specified

Hematopoietic:

• See Disease Characteristics

Hepatic:

• Bilirubin less than 2.5 mg/dL

• SGOT less than 5 times upper limit of normal

Renal:

• Creatinine normal for age OR

• Creatinine clearance or glomerular filtration rate greater than 50% lower limit of normal for age

Cardiovascular:

• If symptomatic:

• LVEF greater than 40% (or shortening fraction greater than 26%) and improves with exercise OR

• Shortening fraction greater than 26%

Pulmonary:

• If symptomatic:

• DLCO, FEV_1, and FEC greater than 45% predicted OR

• Oxygen saturation greater than 85% on room air

Other:

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective contraception

• HIV negative

• No uncontrolled viral, bacterial, or fungal infection

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• See Disease Characteristics

• At least 1 year since prior allogeneic stem cell transplantation (SCT) with cytoreductive preparative therapy

• At least 6 months since prior autologous SCT

• No concurrent thrombopoietic growth factors

Chemotherapy:

• See Disease Characteristics

• See Biologic therapy

Endocrine therapy:

• Not specified

Radiotherapy:

• Not specified

Surgery:

• Not specified

Study Design

Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Leukemia
• Lymphoma
• Myelodysplastic Syndromes
• Myelodysplastic-Myeloproliferative Diseases
• Myelodysplastic/Myeloproliferative Diseases
• Myeloproliferative Disorders
• Preleukemia

Intervention

Biological:
• anti-thymocyte globulin

• filgrastim

Drug:
• busulfan

• cyclophosphamide

• methylprednisolone

Procedure:
• umbilical cord blood transplantation

Radiation:
• radiation therapy

Locations

Country	Name	City	State
United States	Warren Grant Magnuson Clinical Center	Bethesda	Maryland
United States	Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support	Bethesda	Maryland
United States	Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute	Boston	Massachusetts
United States	Cincinnati Children's Hospital Medical Center	Cincinnati	Ohio
United States	Ireland Cancer Center	Cleveland	Ohio
United States	Medical City Dallas Hospital	Dallas	Texas
United States	City of Hope Comprehensive Cancer Center	Duarte	California
United States	Duke Comprehensive Cancer Center	Durham	North Carolina
United States	Spectrum Health and DeVos Children's Hospital	Grand Rapids	Michigan
United States	Cancer Center at Hackensack University Medical Center	Hackensack	New Jersey
United States	Indiana University Cancer Center	Indianapolis	Indiana
United States	Children's Mercy Hospital	Kansas City	Missouri
United States	Children's Hospital Los Angeles	Los Angeles	California
United States	Jonsson Comprehensive Cancer Center, UCLA	Los Angeles	California
United States	North Shore University Hospital	Manhasset	New York
United States	University of Minnesota Cancer Center	Minneapolis	Minnesota
United States	Children's Hospital of New Orleans	New Orleans	Louisiana
United States	Children's Hospital of Orange County	Orange	California
United States	Children's Hospital of Pittsburgh	Pittsburgh	Pennsylvania
United States	James P. Wilmot Cancer Center at University of Rochester Medical Center	Rochester	New York
United States	Cardinal Glennon Children's Hospital	Saint Louis	Missouri
United States	Fred Hutchinson Cancer Research Center	Seattle	Washington
United States	Children's National Medical Center	Washington	District of Columbia

Sponsors (3)

Lead Sponsor	Collaborator
Fred Hutchinson Cancer Research Center	National Cancer Institute (NCI), National Heart, Lung, and Blood Institute (NHLBI)

Country where clinical trial is conducted

United States,