Lymphoma Clinical Trial
Official title:
Oral Combination Chemotherapy in the Treatment of AIDS-Associated Hodgkin's Disease
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die. Combining more than one drug may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy with
lomustine, etoposide, cyclophosphamide, and procarbazine in treating patients with stage
IIB, stage III, or stage IV AIDS-related Hodgkin's disease.
OBJECTIVES:
- Determine the objective response rate, response duration, and survival of patients
receiving lomustine/etoposide/cyclophosphamide/procarbazine (CECP) for stage IIB-IV
AIDS-related Hodgkin's disease.
- Assess the feasibility and toxic effects of CECP in this patient population.
OUTLINE: Patients receive oral lomustine on day 1, oral etoposide on days 1-3, and oral
cyclophosphamide and procarbazine on days 22-31. Filgrastim (granulocyte colony-stimulating
factor) is given subcutaneously on days 5-21 and 33-42. The course is repeated every 6
weeks.
Patients with a complete or partial response after 1 course of treatment receive two
additional courses, but lomustine is omitted in the second course. Patients with partial
response or stable disease receive radiation therapy and/or continued chemotherapy. Patients
failing to respond after 1 course are removed from the study.
Patients will be followed every 3 months until death.
PROJECTED ACCRUAL: A minimum of 16 evaluable patients will be accrued.
;
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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