Lymphoma Clinical Trial
Official title:
CURRENT PRACTICE STUDY OF ANTIBIOTIC TREATMENT OF GASTRIC MALT LYMPHOMA
RATIONALE: Antibiotic therapy and antacids are used to treat Helicobacter pylori infection of
the stomach. These treatments may also have an effect on gastric MALT lymphoma of the
stomach.
PURPOSE: Phase II trial to study the effectiveness of antibiotic therapy with amoxicillin,
clarithromycin, tetracycline, and metronidazole plus antacids in patients with MALT lymphoma
of the stomach.
OBJECTIVES: I. Evaluate the response of gastric lymphoma of mucosa-associated lymphoid tissue
(MALT) to treatment for Helicobacter pylori infection with antibiotics (amoxicillin,
clarithromycin, tetracycline, and metronidazole) and with gastric acid inhibitors (omeprazole
and bismuth subsalicylate). II. Correlate response with endoscopic tumor grade and clinical
and pathological parameters. III. Assess the incidence of H. pylori infection in patients
with gastric MALT lymphoma.
OUTLINE: All patients are treated on Regimen A; those receiving tetracycline on Regimen A are
switched to Regimen B for their second course; those receiving amoxicillin for their first
course receive tetracycline for their second course. Regimen A: Antibiotic Therapy with
Gastric Acid Inhibition. Amoxicillin (or Tetracycline in penicillin-allergic patients);
Clarithromycin; with Bismuth Subsalicylate; Omeprazole. Regimen B: Antibiotic Therapy with
Gastric Acid Inhibition. Tetracycline; Metronidazole, METRO, NSC-50364; with Bismuth
Subsalicylate; Omeprazole.
PROJECTED ACCRUAL: 75 patients will be entered over 3 years.
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