Lymphoma Clinical Trial
Official title:
A RANDOMIZED PROSPECTIVE TRIAL OF CHOP VERSUS MCOP IN ELDERLY PATIENTS WITH INTERMEDIATE AND HIGH GRADE NON-HODGKIN'S LYMPHOMA (AGED 65 YEARS AND OVER)
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die. Combining more than one drug may kill more tumor cells.
PURPOSE: Randomized phase III trial to compare the effectiveness of combination chemotherapy
consisting of cyclophosphamide, vincristine, and prednisolone, with either mitoxantrone or
doxorubicin in treating patients with intermediate- or high-grade non-Hodgkin's lymphoma.
OBJECTIVES: I. Assess the treatment-related neurologic and hematologic toxicities of
patients aged 65 years and over with intermediate- or high-grade non-Hodgkin's lymphoma
randomized to CHOP (cyclophosphamide, doxorubicin, vincristine, prednisolone) vs. MCOP
(mitoxantrone, cyclophosphamide, vincristine, prednisolone). II. Compare the survival rate
in these patients.
OUTLINE: Randomized study. The following acronyms are used: CHOP CTX/DOX/VCR/PRDL CTX
Cyclophosphamide, NSC-26271 DHAD Mitoxantrone, NSC-301739 DOX Doxorubicin, NSC-123127 MCOP
DHAD/CTX/VCR/PRDL PRDL Prednisolone, NSC-9900 VCR Vincristine, NSC-67574 Arm I: 4-Drug
Combination Chemotherapy. CHOP. Arm II: 4-Drug Combination Chemotherapy. MCOP.
PROJECTED ACCRUAL: A total of 200 patients will be entered over approximately 5 years.
;
Allocation: Randomized, Primary Purpose: Treatment
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