Lymphoma, Non-Hodgkin Clinical Trial
Official title:
Phase I, Dose-Escalation Study of Iodine-131 Anti-B1 Antibody for Patients With Previously Treated Non Hodgkin's Lymphoma With More Than 25% Bone Marrow Involvement
This is a phase I, dose escalation, open-label, multicenter study of iodine-131 Anti-B1
Antibody for patients with non-Hodgkin's lymphoma (NHL) who have more than 25% bone marrow
involvement with NHL. Prior studies with Iodine-131 Anti B1 Antibody for the treatment of NHL
have excluded patients with more than 25% bone marrow involvement with NHL. To be eligible,
patients must have been previously treated and failed to achieve an objective response on or
relapse during or following their last treatment.
Patients will undergo two dosing phases while on study. In the first phase, termed the
"dosimetric dose", patients will receive 450 mg unlabeled Anti-B1 Antibody infused over 1
hour or longer followed by 35 mg of Anti-B1 Antibody of which 1-2 mg has been labeled with 5
mCi of Iodine-131 infused over 20 minutes. Whole body camera scans will be obtained on Day 0,
Day 2, 3, or 4, and Day 6 or 7 following the dosimetric dose. Using dosimetric data from
three imaging time points, a patient-specific dose of Iodine-131 Anti-B1 Antibody to deliver
the desired total body dose of radiotherapy will be calculated. In the second phase, termed
the "therapeutic dose", 450 mg Anti-B1 Antibody will be infused over 1 hour or longer
followed by 35 mg of Anti-B1 Antibody labeled with the subject-specific dose of Iodine-131 to
deliver the desired total body radiation, infused over 20 minutes. The dose escalation will
be initiated at 45 cGy and will be increased in 10 cGy increments until the maximum tolerated
dose (MTD) is reached.
Patients will be treated with either saturated potassium iodide, Lugol's solution, or
potassium iodide tablets starting at least 24 hours prior to the infusion of the dosimetric
dose and continuing for 14 days following the last infusion of the therapeutic dose.
The primary endpoint is to determine the maximum tolerated dose of Iodine-131 Anti B-1
Antibody in patients with previously treated NHL having more than 25% bone marrow involvement
with lymphoma. Secondary endpoints include assessment of response rate, duration of response,
relapse-free survival, time to treatment failure, safety, and survival.
n/a
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