Lymphoma, Non-Hodgkin Clinical Trial
| NCT number | NCT00045864 |
| Other study ID # | IL2NHL05 |
| Secondary ID | |
| Status | Completed |
| Phase | Phase 2 |
| First received | September 12, 2002 |
| Last updated | February 2, 2006 |
| Verified date | February 2006 |
| Source | Chiron Corporation |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | United States: Food and Drug Administration |
| Study type | Interventional |
The purpose of this study is to determine the safety and effectiveness of combination therapy with Proleukin and Rituxan on patients with intermediate-and high- grade Non-Hodgkin's lymphoma.
| Status | Completed |
| Enrollment | 0 |
| Est. completion date | |
| Est. primary completion date | |
| Accepts healthy volunteers | No |
| Gender | Both |
| Age group | 18 Years and older |
| Eligibility |
Inclusion: - Diagnosis: CD20+ B-cell non-Hodgkin's lymphoma (NHL) classified as intermediate- or high-grade according to the Working Formulation, subtypes D to H. Must have measureable progressive or refractory disease after no more than three prior chemotherapy regimens. Exclusion: - Clinically significant cardiac dysfunction, or a history of myocardial infarction or heart failure within 6 months of first study treatment - Clinically significant pulmonary dysfunction. - Liver disease (note hepatitis C seropositive subjects may be enrolled if they have no active disease as demonstrated by undetectable HCV viral loads, biopsy showing no active disease, and/or history of normal transaminases on at least three different dates within one year of first study treatment). - Symptomatic thyroid disease requiring medical intervention other than replacement treatment for hypothyroidism. - History of autoimmune disease. - History of positive serology for human immunodeficiency virus (HIV). |
Primary Purpose: Treatment
| Country | Name | City | State |
|---|---|---|---|
| United States | Cancer Care Center | Bloomington | Indiana |
| United States | Our Lady of Mercy Medical Center, Comprehensive Cancer Center | Bronx | New York |
| United States | Gabrail Cancer Center | Canton | Ohio |
| United States | Northwestern University, Feinberg School of Medicine | Chicago | Illinois |
| United States | Rush Cancer Institute | Chicago | Illinois |
| United States | Oncology Hematology Care Inc. | Cincinnati | Ohio |
| United States | The Cleveland Clinic Foundation | Cleveland | Ohio |
| United States | Hematology /Oncology Consultants Inc. | Columbus | Ohio |
| United States | Cancer Specialists of South Texas, P.A. | Corpus Christi | Texas |
| United States | Roger Maris Health System | Fargo | North Dakota |
| United States | Germantown Cancer Center | Germantown | Tennessee |
| United States | Cancer Centers of the Carolinas | Greenville | South Carolina |
| United States | East Carolina University School of Medicine/ Division of Hematology/Oncology | Greenville | North Carolina |
| United States | Kansas City Oncology and Hematology Group | Kansas City | Missouri |
| United States | Dartmouth-Hitchcock-Medical Center | Lebanon | New Hampshire |
| United States | Consultants in Blood Disorders and Cancer | Louisville | Kentucky |
| United States | Division of Hematology/Oncology, University of Miami School of Medicine | Miami | Florida |
| United States | Vanderbilt University Medical Center | Nashville | Tennessee |
| United States | Memorial Sloan Kettering Cancer Center | New York | New York |
| United States | Hoag Cancer Center | Newport Beach | California |
| United States | Oncology Specialists, S.C. | Park Ridge | Illinois |
| United States | University of Pennsylvania | Philadelphia | Pennsylvania |
| United States | Oregon Heath and Science University | Portland | Oregon |
| United States | Virginia Cancer Institute | Richmond | Virginia |
| United States | UC Davis Cancer Center | Sacramento | California |
| United States | John Wayne Cancer Institute | Santa Monica | California |
| United States | Louisiana Health Sciences Center, Department of Medicine, Hematology/Oncology | Shreveport | Louisiana |
| United States | Arch Medical Group, LLC | St. Louis | Missouri |
| United States | Stanford University Medical Center | Stanford | California |
| United States | ACRC/Arizona Clinical Research Center, Inc. | Tucson | Arizona |
| United States | Georgetown University Medical Center, Lombardi Cancer Center | Washington | District of Columbia |
| United States | Washington Cancer Institute | Washington | District of Columbia |
| United States | California Cancer Medical Center | West Covina | California |
| Lead Sponsor | Collaborator |
|---|---|
| Chiron Corporation |
United States,
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05540340 -
A Study of Melphalan in People With Lymphoma Getting an Autologous Hematopoietic Cell Transplant
|
Phase 1 | |
| Recruiting |
NCT04460235 -
Immunogenicity of an Anti-pneumococcal Combined Vaccination in Acute Leukemia or Lymphoma
|
Phase 4 | |
| Completed |
NCT03484702 -
Trial to Determine the Efficacy and Safety of JCAR017 in Adult Participants With Aggressive B-Cell Non-Hodgkin Lymphoma
|
Phase 2 | |
| Completed |
NCT01410630 -
FLT-PET/CT vs FDG-PET/CT for Therapy Monitoring of Diffuse Large B-cell Lymphoma
|
||
| Active, not recruiting |
NCT05024045 -
Study of Oral LOXO-338 in Patients With Advanced Blood Cancers
|
Phase 1 | |
| Completed |
NCT06190457 -
Safety and Efficacy of Intrathecal Rituximab in 16 Children of Stage Ⅲ、ⅣNon-Hodgkin Lymphoma
|
||
| Completed |
NCT02369016 -
Phase III Copanlisib in Rituximab-refractory iNHL
|
Phase 3 | |
| Recruiting |
NCT01676805 -
Tissue Collection for Studies of Lymph Cancer
|
||
| Terminated |
NCT00916045 -
Pilot Study of Unrelated Cord Blood Transplantation
|
Phase 2 | |
| Completed |
NCT00534989 -
Use of FDG PET as Predictor of Residual Disease and Subsequent Relapse in Patients With NHL and HD Undergoing HDC and ASCT
|
N/A | |
| Terminated |
NCT00529503 -
A Randomized Phase IIb Placebo-Controlled Study of R-ICE Chemotherapy With and Without SGN-40 for Patients With DLBCL
|
Phase 2 | |
| Withdrawn |
NCT00538096 -
A Phase I Study to Evaluate Safety, Tolerability in Adults With Lymphoma
|
Phase 1 | |
| Completed |
NCT00156013 -
Clofarabine for Relapsed or Refractory T-Cell or B-Cell Non-Hodgkin Lymphoma (NHL)
|
Phase 1/Phase 2 | |
| Withdrawn |
NCT00319332 -
A Comparative Study Of Iodine I 131 Tositumomab Therapeutic Regimen Versus Ibritumomab Tiuxetan Therapeutic Regimen
|
Phase 3 | |
| Completed |
NCT00141297 -
A Study Of Oral Palbociclib (PD-0332991), A Cyclin-Dependent Kinase Inhibitor, In Patients With Advanced Cancer
|
Phase 1 | |
| Completed |
NCT00322842 -
Treatment With AMD3100 (Plerixafor) in Non-Hodgkin's Lymphoma and Multiple Myeloma Patients
|
Phase 2 | |
| Completed |
NCT02509039 -
A Study of CC-122 to Assess the Safety and Tolerability in Japanese Patients With Advanced Solid Tumors and Non-Hodgkin's Lymphoma (NHL)
|
Phase 1 | |
| Completed |
NCT01573000 -
A Randomized Study of Iodine-131 Anti-b1 Antibody Versus Anti-b1 Antibody in Chemotherapy-relapsed/Refractory Low-grade or Transformed Low-grade Non-Hodgkin's Lymphoma (NHL)
|
Phase 2 | |
| Completed |
NCT00268203 -
Expanded Access Study Of BEXXAR® For Low Grade And Transformed Low-Grade Non-Hodgkin's Lymphoma
|
Phase 2 | |
| Completed |
NCT03289182 -
An Observational Study of MabThera Subcutaneous (SC) Safety in Participants With Non-Hodgkin's Lymphoma (NHL) or Chronic Lymphocytic Leukemia (CLL)
|