Lymphoma, B-Cell Clinical Trial
Official title:
Lenalidomide, Rituximab and Combination Chemotherapy Versus Rituximab and Combination Chemotherapy in Treating Patients With Newly Diagnosed Highly Aggressive Non-Hodgkin B-cell Lymphoma
In this study，lenalidomide was added in the first-line treatment in the newly diagnosed highly invasively non-Hodgkin B-cell lymphoma. The R2-CHOP/R2-EPOCH etc was applied compared with the classical R-CHOP/R-EPOCH etc. The investigators tried to explore a more effective and safe treatment regimen for patients with high-risk B-cell lymphoma to improve the patient's poor prognosis.
Lymphoma has become one of the top ten malignant tumors, of which non-Hodgkin's B-cell
lymphoma accounts for the majority. As the classic first-line treatment, the emergence of the
R-CHOP program has resulted in clinical cures for more than 1/2 of patients with B-cell
lymphoma. But for patients with highly aggressively B cell lymphoma, most of them still
suffer from disease recurrences due to R-CHOP treatment alone.
In recent years, with the emergence of various new drugs, many researchers have tried to add
new drugs to the classic R-CHOP program as a first-line treatment for non-Hodgkin B-cell
lymphoma. As a new type of immunomodulator, lenalidomide was first approved for the treatment
of multiple myeloma. In recent years, its role in refractory and relapsed B-cell lymphoma has
gradually been recognized.
In 2015, Nowakowski et al. published a clinical study of 64 patients with diffuse large
B-cell lymphoma who used R2-CHOP in first-line therapy. It was found that R2-CHOP does not
improve R-CHOP in patients with GCB. The effective rate of treatment and the 2-year survival
rate of patients, but for patients with non-GCB type DLBCL with poor prognosis, the addition
of lenalidomide can greatly improve the remission rate of the disease and improve the poor
prognosis of patients.
So, the investigators initiate this study to evaluate the efficacy of R2-CHOP/R2-EPOCH etc in
newly diagnosed highly invasively non-Hodgkin B-cell lymphoma.
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