Lymphedema Clinical Trial
Official title:
The Role of Pyroptosis and Ferroptosis in the Pathophysiology of Lymphedema
The project aims to compare the differences in the expression of cell death through apoptosis and iron-dependent cell death after the reduction of edema symptoms following lymphedema surgery in patients.
Status | Recruiting |
Enrollment | 120 |
Est. completion date | January 12, 2026 |
Est. primary completion date | September 20, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 20 Years to 100 Years |
Eligibility | Inclusion Criteria: - Control Group: Patients who have not experienced lymphedema but require surgery due to other diseases such as cancer, trauma, chronic wounds, skin defects, etc. - Experimental Group: Patients who have lymphedema and undergone lymphedema surgery. Exclusion Criteria: - 1. Individuals with venous thrombosis, chronic heart failure, and renal failure. - 2. Vulnerable populations, individuals with limited mobility, pregnant women, and minors. - 3. Those expected to be unable to attend follow-up visits or complete the study smoothly. - 4. Participants who express doubts about the trial and cannot provide satisfactory answers. |
Country | Name | City | State |
---|---|---|---|
Taiwan | Kaohsiung Chang Gung Memorial Hospital | Kaohsiung |
Lead Sponsor | Collaborator |
---|---|
Chang Gung Memorial Hospital |
Taiwan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The correlation between post-LVA volume reduction | The differences in expression of cell necrosis and iron-dependent cell death after lymphedema surgery were observed in patients, following alleviation of edema symptoms. | 1 month after surgery |
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