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Contrast-Enhanced Ultrasound and Shear Wave Elastography for the Treatment of Lymphedema — CASTLE  

Lymphedema Arm Clinical Trial

Official title:
Contrast-enhanced Ultrasound and Shear Wave Elastography for the Treatment of Lymphedema (CASTLE) Study

Clinical Trial Summary

The purpose of this research is to determine the preferred microbubble agent (Lumason®, Optison®, and Definity®) for lymphatic channel visualization by ultrasound. This research will also evaluate the utility of preoperative high-frequency B-mode ultrasound with contrast-enhanced ultrasound for presurgical planning, and ultrasound shear wave elastography for assessing treatment response at 6-month follow up.

Clinical Trial Description

Part 1 - Evaluate the uptake of microbubble agent (Lumason®, Optison®, and Definity®) for lymphatic visualization by ultrasound. Part 2 - Combine preoperative high-frequency B-mode ultrasound with contrast-enhanced ultrasound to identify patent lymphatic channels for lymphaticovenous anastomosis presurgical planning. Evaluate the utility of ultrasound shear wave elastography for assessing treatment response at 6-month follow up. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05613946
Study type Interventional
Source Mayo Clinic
Contact
Status Active, not recruiting
Phase Phase 1
Start date December 15, 2022
Completion date June 30, 2024
View Details
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