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Lymphatic Malformations clinical trials

View clinical trials related to Lymphatic Malformations.

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NCT ID: NCT03427619 Completed - Clinical trials for Lymphatic Malformations

OK432 (Picibanil) in the Treatment of Lymphatic Malformations

Start date: October 5, 2005
Phase: Phase 2
Study type: Interventional

Standard of care for Lymphatic Malformations has been surgical excision. We have been using OK432/Picibanil (generously supplied by Chugai Pharmaceuticals in Japan) since 1992 with great success for macrocystic disease. The objective of the study was to provide OK-432 immunotherapy to subjects with macrocystic or mixed (> 50% macrocystic) lymphatic malformations (LMs) and investigate the efficacy and safety of OK 432 as a treatment option in subjects with LMs.

NCT ID: NCT02335242 Completed - Lymphatic Diseases Clinical Trials

Sildenafil for the Treatment of Lymphatic Malformations

Start date: May 23, 2015
Phase: Phase 2
Study type: Interventional

A Phase 2 study to evaluate safety and efficacy of sildenafil taken orally to improve or resolve lymphatic malformations in children. Subjects may receive either placebo or treatment in an oral dosage with an open label extension for subjects who received placebo. The study treatment assignment will be randomized in a double blind fashion. MRI examination will evaluate change in lesion volume due to treatment. Other safety and efficacy measures will be taken through the 32-week study duration. Funding Source - FDA OOPD

NCT ID: NCT00866827 Completed - Clinical trials for Lymphatic Malformations

Airway Vascular Lesions

Start date: December 2002
Phase:
Study type: Observational

Controversy exists in the treatment of airway hemangiomas ranging from tracheotomy, various lasers, to open removal, none of which have proven to be a gold standard. Venous malformations of the airway are difficult to treat and also require laser therapy or open removal and often repeated treatments are required. Similarly airway lymphatic malformations can require multiple treatment modalities as well as multiple procedures and are infrequently eradicated when extensive. New uses for various lasers and differing treatment protocols are frequently developed. Review of the treatment modalities and efficacy of these methods is required. The goal of this research is to determine protocols for treatment of airway vascular malformation and to evaluate our results from treatment of these lesions.

NCT ID: NCT00577213 Completed - Clinical trials for Arteriovenous Malformations

Diagnosis of Hemangiomas and Vascular Malformations

Start date: February 2007
Phase: N/A
Study type: Observational

To develop a non-invasive, simple and affordable, measurement technique to differentiate hemangiomas from subtypes of VMS. The purpose of this study is to determine the best office based diagnositc instrument for differentiating the subtype of vascular lesions. The instrument must be simple and affordable so it can be used by primary car physicians in the doctor office. The procedure will be based on non-invasive and unharmful measurements that will be compared to the diagnosis from specialized physicians in this field and the final pathology.

NCT ID: NCT00010452 Completed - Clinical trials for Lymphatic Malformations

Study of Picibanil (OK432) Sclerotherapy in Children With Macrocystic Lymphatic Malformations

Start date: April 2000
Phase: Phase 2/Phase 3
Study type: Interventional

OBJECTIVES: I. Determine the efficacy of picibanil sclerotherapy in children with macrocystic lymphangioma.