Lymphatic Filariasis Clinical Trial
Official title:
Spontaneous Antigenemia in Loiasis, A Study of the Loiasis Antigens Responsible for Cross-reactivity in the Rapid Diagnostic Test for Lymphatic Filariasis
This prospective study will enroll and follow 60 loiasis patients with high worm burden to monitor the spontaneous release of filarial antigen in peripheral blood. This study will define the cross-reactive antigen profile of persons with spontaneous loiasis antigenemia, and determine whether it varies with time.
Global efforts to eradicate lymphatic filariasis (LF) depend on rapid diagnostic tests (RDTs)
that detect Wuchereria bancrofti circulating filarial antigen but these tests are unreliable
in African nations where Loa loa is co-endemic because they yield false-positive results in
some individuals with loiasis. The goals of this project are to define the cross-reactive
antigen profile of persons with spontaneous antigenemia, how it varies over time, and to
determine which L. loa antigens in cross-reactive sera best distinguish loiasis
cross-reactivity from LF.
This prospective study will prospectively enroll 50 adults who presented with cross-reactive
antigenemia at screening and 10 negative controls. Participants will followed for one year
and tested every three months for persistence of antigenemia.
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