Impact of Albendazole -Ivermectin on Wuchereria Bancrofti in Mali

Status Completed

Clinical Trial Summary

Clinical Trial Description

Lymphatic filariasis is a public health problem in Mali. The existing data are not up to date and most of them are more than 15 years old. To address this issue in April 2000, the investigators started studies to update the epidemiology of lymphatic filariasis. As a result, in two rural areas (Banambani and Sirakoro) located at about 25 km North-East Bamako, the parasite prevalence using ICT cards in August 2000 were 16% (n=150) and 15.0% (n=113) respectively in Banambani and Sirakoro. There is no ongoing lymphatic filariasis control program in 2000 in Mali in terms of preventive chemotherapy treatment or vector control.

To fill these gaps, this current study aims to assess the impact of albendazole-ivermectin combination treatment on Wuchereria bancrofti infection and transmission in 6 rural highly endemic villages of Mali.

The study will be conducted in three phases: the pre treatment assessment of lymphatic filariasis infection and transmission parameters, treatment phase with annual single dose of albendazole and ivermectin and the post treatment assessment of Anopheles gambiae s.l mosquitoes, the transmission parameters of the vectors in the community, human infection prevalence post treatment using Giemsa -stained thick smears and others test like the Immuno chromatographic test (ICT). ;

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02784743
Study type	Interventional
Source	Centre d'Appui à la lutte contre la Maladie
Contact
Status	Completed
Phase	Phase 4
Start date	May 2001
Completion date	April 2015

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT00375583` - Effect of Albendazole Dose on Clearance of Filarial Worms	Phase 2
Completed	`NCT03664063` - PK PD Study of IDA and Azithromycin for NTDs ( ComboNTDs )	Phase 2
Recruiting	`NCT04844905` - Adjunctive Ivermectin Mass Drug Administration for Malaria Control	Phase 3
Completed	`NCT01975441` - Eval 3-Drug Therapy Diethylcarbamize, Albendazole and Ivermectin That Could Accelerate LF Elimination Outside of Africa	Phase 2
Completed	`NCT01629771` - Disability and Quality of Life in Patients With Lymphatic Filariasis in Rural Southern India	N/A
Completed	`NCT01905423` - Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis
Completed	`NCT03036059` - Twice Yearly Treatment for the Control of LF	Phase 4
Completed	`NCT01905436` - Mass Drug Administration for Lymphatic Filariasis and Onchocerciasis for Liberia
Completed	`NCT02509481` - Repeat Ivermectin Mass Drug Administrations for Control of Malaria: a Pilot Safety and Efficacy Study	Phase 2/Phase 3
Completed	`NCT03268252` - Optimization of MDA With Existing Drug Regimens for LF: Monitoring Efficacy of Ongoing Treatment Programs in PNG
Completed	`NCT02927496` - A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali	Phase 3
Completed	`NCT02899936` - Death to Onchocerciasis and Lymphatic Filariasis (DOLF) Triple Drug Therapy for Lymphatic Filariasis	N/A
Completed	`NCT00511004` - Effect of Albendazole Dose on Treatment of Lymphatic Filariasis	Phase 2
Active, not recruiting	`NCT04258670` - Spontaneous Antigenemia in Loiasis
Completed	`NCT02974049` - Lymphatic Filariasis (LF) in Ivory Coast	N/A
Terminated	`NCT01213576` - Efficacy of Higher Albendazole and Ivermectin Doses on Wuchereria Bancrofti Microfilarial Clearance in Malawi	N/A
Completed	`NCT02929121` - A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in India	Phase 3
Completed	`NCT00339417` - Effect of Albendazole Dose on Clearance of Filarial Worms	Phase 2
Completed	`NCT02032043` - Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Ivory Coast (DOLF-Ivory Coast)
Withdrawn	`NCT01903057` - Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis	Phase 4

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.